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Serum brain-derived neurotrophic factor differences between the luteal and follicular phases in premenstrual dysphoric disorder.
Oral, Elif; Kirkan, Tulay Sati; Yildirim, Abdulkadir; Kotan, Zerrin; Cansever, Zeliha; Ozcan, Halil; Aliyev, Elvin; Gulec, Mustafa.
Afiliação
  • Oral E; Department of Psychiatry, Medical Faculty, Ataturk University, Erzurum, Turkey. Electronic address: oralelif@yahoo.com.
  • Kirkan TS; Department of Psychiatry, Erzurum Regional Training and Research Hospital, Erzurum, Turkey.
  • Yildirim A; Department of Biochemistry, Medical Faculty, Ataturk University, Erzurum, Turkey.
  • Kotan Z; Department of Biochemistry, Pharmacy Faculty, Ataturk University, Erzurum, Turkey.
  • Cansever Z; Department of Medical Education, Medical Faculty, Ataturk University, Erzurum, Turkey.
  • Ozcan H; Department of Psychiatry, Medical Faculty, Ataturk University, Erzurum, Turkey.
  • Aliyev E; Department of Biochemistry, Medical Faculty, Ataturk University, Erzurum, Turkey.
  • Gulec M; Department of Psychiatry, Medical Faculty, Katip Celebi University, Izmir, Turkey.
Gen Hosp Psychiatry ; 37(3): 266-72, 2015.
Article em En | MEDLINE | ID: mdl-25799087
ABSTRACT

OBJECTIVE:

We hypothesized that comparison of the serum brain-derived neurotrophic factor (BDNF) levels between women with premenstrual dysphoric disorder (PMDD) and women without PMDD in the luteal and follicular phases of their menstrual cycles would reflect the altered neuromodulator responses that compensate the underlying pathogenesis in PMDD.

METHOD:

Twenty-nine participants without PMDD and 20 with PMDD were enrolled in the study. The serum BDNF, estrogen and progesterone levels were assessed at the follicular and luteal phases in their two consecutive menstrual cycles.

RESULTS:

Participants with PMDD had significantly higher luteal serum BDNF levels than the control subjects. The serum BDNF levels were significantly higher in the luteal phase than in the follicular phase in women with PMDD. The difference in the serum BDNF levels between the luteal and follicular phases were significantly higher in the PMDD patients than in the control.

CONCLUSIONS:

The higher serum BDNF levels in the luteal phase in the PMDD patients may reflect compensatory process that results in subsequent improvement of the PMDD-associated depressive symptoms in the follicular phase. The higher difference in the serum BDNF levels between the phases in PMDD patients may reflect an altered neuromodulator response.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator Neurotrófico Derivado do Encéfalo / Transtorno Disfórico Pré-Menstrual / Fase Folicular / Fase Luteal Limite: Adult / Female / Humans Idioma: En Revista: Gen Hosp Psychiatry Ano de publicação: 2015 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator Neurotrófico Derivado do Encéfalo / Transtorno Disfórico Pré-Menstrual / Fase Folicular / Fase Luteal Limite: Adult / Female / Humans Idioma: En Revista: Gen Hosp Psychiatry Ano de publicação: 2015 Tipo de documento: Article
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