Double-faceted mechanism of parvoviral oncosuppression.
Curr Opin Virol
; 13: 17-24, 2015 Aug.
Article
em En
| MEDLINE
| ID: mdl-25841215
ABSTRACT
The H-1 parvovirus (H-1PV) exerts oncosuppressive action that has two components oncotoxicity and immunostimulation. While many human tumor cells, including conventional drug-resistant ones, can be killed by H-1PV, some fail to support progeny virus production, necessary for infection propagation in neoplastic tissues. This limitation can be overcome through forced selection of H-1PV variants capable of enhanced multiplication and spreading in human tumor cells. In the context of further developing H-1PV for use in cancer therapy, arming it with immunostimulatory CpG motifs under conditions preserving replication and oncolysis enhances its action as an anticancer vaccine adjuvant. A first clinical study of H-1PV treatment in glioma patients has yielded evidence of intratumoral synthesis of the viral oncotoxic protein NS1 and immune cell infiltration.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Alphaherpesvirinae
/
Vírus Oncolíticos
/
Parvovirus H-1
/
Neoplasias
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Virol
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Alemanha