Preparation and application of micro/nanoparticles based on natural polysaccharides.

ABSTRACT

Polysaccharides have attracted more and more attentions and been recognized to be the most promising materials in recent years because of their outstanding merits such as easily available, non-toxic, biocompatible, biodegradable, and easily modified. Considerable research efforts have been directed toward developing polysaccharides-based micro/nanoparticles (PM/NPs). The new major studies of PM/NPs over the past few years are outlined in this review. Methods of preparation, including self-assembly, ionic-gelation, complex coacervation, emulsification, and desolvation method and some others, are summarized. Different applications of PM/NPs in the field of drug-delivery system are highlighted. Besides, another novel application of PM/NPs that are used as emulsifiers to stabilize Pickering emulsion is also introduced. These environmental-friendly particle emulsifiers have received reasonable attention due to their novel applications, especially in food, cosmetics, and pharmaceutics. From literature surveys, we realized that studies on PM/NP systems for different applications have increased rapidly. Hence, the present review is timely.