[Cardiac adverse effects of domperidone in adult patients: a systematic review]. / Efectos adversos cardíacos de la domperidona en pacientes adultos: revisión sistemática.
Rev Med Chil
; 143(1): 14-21, 2015 Jan.
Article
em Es
| MEDLINE
| ID: mdl-25860264
ABSTRACT
BACKGROUND:
Domperidone is widely prescribed in patients with gastrointestinal disorders but some cardiac adverse effects have been recently reported.AIM:
To evaluate the risk of QT prolongation, ventricular arrhythmias and sudden cardiac death associated with the use of oral domperidone in adults without cancer. MATERIAL ANDMETHODS:
Systematic searches in MEDLINE, LILACS, SciELO, the Cochrane Library and regulatory agencies websites were performed, followed by a manual search of cited references. The search strategy consisted of combining free and indexed text words without any date or language restriction.RESULTS:
Three case-control studies met the inclusion criteria; none of them evaluated QT interval prolongation. With low risk of bias, each study quantified the risk of ventricular arrhythmia or sudden cardiac death (VA/SCD). The odds ratios for these events in these studies were 4.7 (95% confidence interval (CI) 1.4-16), 1.59 (95% CI 1.28-1.98) and 11.02 (95% CI 2.02-62.3) respectively. A significantly increased risk was observed in patients older than 60 years of age or receiving doses > 30 mg/day.CONCLUSIONS:
Heterogeneity between selected studies did not allow the computation of a summary measure. However, evidence was found that an increased risk of VA/SCD is associated with the use of oral domperidone in adults.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Arritmias Cardíacas
/
Morte Súbita Cardíaca
/
Domperidona
/
Antieméticos
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
/
Systematic_reviews
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
Es
Revista:
Rev Med Chil
Ano de publicação:
2015
Tipo de documento:
Article