The expression of Toll-like receptors 2, 4, 5, 7 and 9 in Merkel cell carcinoma.
Anticancer Res
; 35(4): 1843-9, 2015 Apr.
Article
em En
| MEDLINE
| ID: mdl-25862837
ABSTRACT
AIM:
We sought to clarify whether the expression of toll-like receptors (TLR) in Merkel cell carcinoma (MCC) is linked to tumor and patient characteristics, especially the presence of Merkel cell polyoma virus (MCV). MATERIALS ANDMETHODS:
The study comprised of 128 patients with data on Merkel cell polyomavirus (MCV) status and clinical features were included in the study. Immunohistochemistry for TLR expression was performed on tissue microarray (TMA) slides.RESULTS:
TLR 2, 4, 5, 7 and 9 expression was noted in most of the tumor specimens. Decreased expression of TLR 9 correlated strongly with MCV positivity. Cytoplasmic TLR 2 expression correlated with small tumor size, while nuclear TLR 2 and TLR 5 expressions with larger tumors. Increased nuclear TLR 4 expression and decreased TLR 7 expression were associated with older age.CONCLUSION:
TLR 2, 4, 5, 7 and 9 appear to reflect certain clinicopathological variables and prognostic markers of MCC tumors.Palavras-chave
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carcinoma de Célula de Merkel
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Receptor Toll-Like 9
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Receptor 2 Toll-Like
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Receptor 4 Toll-Like
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Receptor 5 Toll-Like
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Receptor 7 Toll-Like
Tipo de estudo:
Prognostic_studies
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Anticancer Res
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Finlândia