Tissue engineering for lateral ridge augmentation with recombinant human bone morphogenetic protein 2 combination therapy: a case report.
Int J Periodontics Restorative Dent
; 35(3): 325-33, 2015.
Article
em En
| MEDLINE
| ID: mdl-25909520
ABSTRACT
This case report describes a tissue-engineered reconstruction with recombinant human bone morphogenetic protein 2/acellular collagen sponge (rhBMP-2/ ACS) + cancellous allograft and space maintenance via Medpor Contain mesh in the treatment of a patient requiring maxillary and mandibular horizontal ridge augmentation to enable implant placement. The patient underwent a previously unsuccessful corticocancellous bone graft at these sites. Multiple and contiguous sites in the maxilla and in the mandibular anterior, demonstrating advanced lateral ridge deficiencies, were managed using a tissue engineering approach as an alternative to autogenous bone harvesting. Four maxillary and three mandibular implants were placed 9 and 10 months, respectively, after tissue engineering reconstruction, and all were functioning successfully after 24 months of follow-up. Histomorphometric analysis of a bone core obtained at the time of the maxillary implant placement demonstrated a mean of 76.1% new vital bone formation, 22.2% marrow/cells, and 1.7% residual graft tissue. Tissue engineering for lateral ridge augmentation with combination therapy requires further research to determine predictability and limitations.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Implantes Dentários
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Fator de Crescimento Transformador beta
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Engenharia Tecidual
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Implantação Dentária Endóssea
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Proteína Morfogenética Óssea 2
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Aumento do Rebordo Alveolar
Tipo de estudo:
Prognostic_studies
Limite:
Adult
/
Humans
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Male
Idioma:
En
Revista:
Int J Periodontics Restorative Dent
Ano de publicação:
2015
Tipo de documento:
Article