Cholinergic agonists selectively induce proliferative responses in the mature subpopulation of murine thymocytes.
J Neurosci Res
; 24(3): 369-73, 1989 Nov.
Article
em En
| MEDLINE
| ID: mdl-2593180
ABSTRACT
The incubation of murine thymocytes for 24 hr in the presence of cholinergic agonists induces selective proliferation of PNA- cells as measured by thymidine incorporation. The response of PNA- cells is mediated by the activation of nicotinic receptors. This conclusion is suggested by the inability of the muscarinic agonist, oxotremorine, to induce cell proliferation and by the inhibition exerted by the nicotinic antagonist, d-tubocurarine. The presence of cholinergic axons in the murine thymus adds biological interest to the selective expression of functional cholinergic receptors on mature thymocytes.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Parassimpatomiméticos
/
Timo
/
Tubocurarina
/
Receptores Nicotínicos
Limite:
Animals
Idioma:
En
Revista:
J Neurosci Res
Ano de publicação:
1989
Tipo de documento:
Article
País de afiliação:
Itália