[Immunohistochemical and clinicopathological studies of chromogranin immunoreactive cells in large bowel carcinoma].
Nihon Geka Gakkai Zasshi
; 90(10): 1742-51, 1989 Oct.
Article
em Ja
| MEDLINE
| ID: mdl-2594002
ABSTRACT
We examined the clinicopathological relevance of chromogranin immunoreactive cells in a well documented series of 212 large bowel cancer patients. Chromogranin immunoreactive cells were detected in 33.5% of the carcinomas, occurring either as rare cases (19.3%) or as diffuse cases (14.2%). The tumors with chromogranin immunoreactivity were associated with a more aggressive clinical course than tumors without immunoreactivity (Generalized-Wilcoxon; p less than 0.08). Moreover, the survival of patients with diffusely immunoreactive tumors was significantly shorter than that of patients without such cells (Generalized-Wilcoxon; p less than 0.009). Therefore, the study of chromogranin immunoreactivity in large bowel carcinomas may enable the identification of a subpopulation of colorectal carcinomas associated with a relatively poor prognosis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cromograninas
/
Neoplasias Intestinais
/
Intestino Grosso
/
Proteínas do Tecido Nervoso
Tipo de estudo:
Prognostic_studies
Limite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Ja
Revista:
Nihon Geka Gakkai Zasshi
Ano de publicação:
1989
Tipo de documento:
Article
País de afiliação:
Japão