Catalytic amidation of unactivated ester derivatives mediated by trifluoroethanol.
Chem Commun (Camb)
; 51(46): 9495-8, 2015 Jun 11.
Article
em En
| MEDLINE
| ID: mdl-25966325
ABSTRACT
A catalytic amidation method has been developed, employing 2,2,2-trifluoroethanol to facilitate condensation of unactivated esters and amines, enabling the synthesis of a range of amide products in good to excellent yields. Mechanistic studies indicate the reaction proceeds through a trifluoroethanol-derived active ester intermediate.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Trifluoretanol
/
Amidas
Idioma:
En
Revista:
Chem Commun (Camb)
Assunto da revista:
QUIMICA
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Reino Unido