Differential response of pig masseter to botulinum neurotoxin serotypes a and b.
Muscle Nerve
; 52(1): 88-93, 2015 Jul.
Article
em En
| MEDLINE
| ID: mdl-26039454
ABSTRACT
INTRODUCTION:
Pigs respond to direct administration of botulinum neurotoxins (BoNTs), although they are resistant to botulism. The human masseter is frequently targeted for BoNT therapy. We aimed to understand how BoNT affects chewing by injecting porcine masseters.METHODS:
One masseter of minipigs was injected with BoNT serotype A or B at doses comparable to those used in humans. Masticatory function was evaluated electromyographically. Muscle force was measured during tetany. Four weeks after injection, strain gauges affixed to the mandible assessed bone strain during chewing. Masseter mass and fiber diameter were measured after euthanasia.RESULTS:
BoNT-A had no measurable effect. In contrast, BoNT-B reduced electrical activity and muscle force, producing substantial asymmetry between injected and uninjected muscles.CONCLUSIONS:
The pig masseter is highly resistant to direct injection of BoNT-A, but it is affected by BoNT-B.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Toxinas Botulínicas Tipo A
/
Músculo Masseter
/
Fármacos Neuromusculares
Limite:
Animals
Idioma:
En
Revista:
Muscle Nerve
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Estados Unidos