Feasibility of use of probabilistic reversal learning and serial reaction time tasks in clinical trials of Parkinson's disease.
Parkinsonism Relat Disord
; 21(8): 894-8, 2015 Aug.
Article
em En
| MEDLINE
| ID: mdl-26040709
INTRODUCTION: The aim of this study was to investigate the feasibility of using two computer-administered neuropsychological tasks in a clinical trial involving participants with Parkinson's disease without dementia. The tasks, probabilistic reversal learning (PRL) and serial reaction time (SRT), target dorsolateral prefrontal cortex (SRT) and ventral striatal-orbitofrontal (PRL) functioning respectively. METHODS: Participants were 53 adults with idiopathic Parkinson's disease who completed both the SRT and PRL tasks at baseline in a clinical trial. Repeated measures were examined only for the placebo group (n = 20). RESULTS: No participants were removed from analyses due to inability to complete the tasks, and most had fewer than 10% of trials culled due to slow reaction times. Response accuracy on PRL was 81.98% and 66.65% for the two stages of the task respectively. Disease duration was associated with SRT relearning. Disease duration and stage were associated with initial learning on PRL, and there was a trend towards disease stage predicting greater errors on PRL. Among participants in the placebo group, practice effects were seen on PRL (Phase 1 errors) and SRT (relearning). CONCLUSIONS: These results provide initial evidence for the clinical feasibility of computerized PRL and SRT tasks in clinical trials in Parkinson's disease.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
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Aprendizagem por Probabilidade
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Tempo de Reação
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Reversão de Aprendizagem
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Ensaios Clínicos como Assunto
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Avaliação de Resultados em Cuidados de Saúde
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Testes Neuropsicológicos
Tipo de estudo:
Clinical_trials
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Prognostic_studies
Limite:
Aged
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Parkinsonism Relat Disord
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2015
Tipo de documento:
Article
País de publicação:
Reino Unido