Interactions of nucleic acids with distamycins. The drug monomeric chromophore.
Biopolymers
; 28(12): 2161-76, 1989 Dec.
Article
em En
| MEDLINE
| ID: mdl-2605315
ABSTRACT
A study of the monomeric chromophore of the oligopeptides netropsin (1), distamycin III (2), and distamycin V (3) by polarization spectroscopy techniques and molecular orbital calculations is reported. Linear dichroism spectra of the monomeric model compounds 1-methyl-2(ethylcarbamoyl)-4-acetamido-pyrrole (4) and 1-methyl-2(ethylcarbamoyl)-pyrrole (5) dissolved and oriented in lyotropic and thermotropic liquid crystals provide, together with the magnetic CD spectra, experimental checks of the theoretical calculations. The polarization directions of the investigated transition obtained by these means in this study allow us to build up in the following paper the exciton states of (1)-(3) and these provide a stereochemical interpretation of the flow linear dichroism spectra of the complexes of DNA with (2) and (3).
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pirróis
/
DNA
/
Distamicinas
Idioma:
En
Revista:
Biopolymers
Ano de publicação:
1989
Tipo de documento:
Article