Metformin's Intrinsic Blood-to-Plasma Partition Ratio (B/P): Reconciling the Perceived High In Vivo B/P > 10 with the In Vitro Equilibrium Value of Unity.

Xie, Fang; Ke, Alice B; Bowers, Gary D; Zamek-Gliszczynski, Maciej J

Xie, Fang; Ke, Alice B; Bowers, Gary D; Zamek-Gliszczynski, Maciej J.

Afiliação

Xie F; Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, North Carolina (F.X., G.D.B., M.J.Z.-G.); and Certara, Cary, North Carolina (A.B.K.).
Ke AB; Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, North Carolina (F.X., G.D.B., M.J.Z.-G.); and Certara, Cary, North Carolina (A.B.K.).
Bowers GD; Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, North Carolina (F.X., G.D.B., M.J.Z.-G.); and Certara, Cary, North Carolina (A.B.K.).
Zamek-Gliszczynski MJ; Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, North Carolina (F.X., G.D.B., M.J.Z.-G.); and Certara, Cary, North Carolina (A.B.K.) maciej.x.zamek-gliszczynski@gsk.com.

J Pharmacol Exp Ther ; 354(2): 225-9, 2015 Aug.

Article em En | MEDLINE | ID: mdl-26062557

Assuntos

Hipoglicemiantes/sangue; Metformina/sangue; Plasma/metabolismo; Animais; Humanos; Hipoglicemiantes/farmacologia; Masculino; Metformina/farmacologia; Plasma/efeitos dos fármacos; Ratos; Ratos Sprague-Dawley

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plasma / Hipoglicemiantes / Metformina Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: J Pharmacol Exp Ther Ano de publicação: 2015 Tipo de documento: Article País de publicação: Estados Unidos

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