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Genetic and chemical validation identifies Mycobacterium tuberculosis topoisomerase I as an attractive anti-tubercular target.
Ravishankar, Sudha; Ambady, Anisha; Awasthy, Disha; Mudugal, Naina Vinay; Menasinakai, Sreenivasaiah; Jatheendranath, Sandesh; Guptha, Supreeth; Sharma, Sreevalli; Balakrishnan, Gayathri; Nandishaiah, Radha; Ramachandran, Vasanthi; Eyermann, Charles J; Reck, Folkert; Rudrapatna, Suresh; Sambandamurthy, Vasan K; Sharma, Umender K.
Afiliação
  • Ravishankar S; AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India. Electronic address: mailsuravi01@gmail.com.
  • Ambady A; AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India.
  • Awasthy D; AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India.
  • Mudugal NV; AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India.
  • Menasinakai S; AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India.
  • Jatheendranath S; AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India.
  • Guptha S; AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India.
  • Sharma S; AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India.
  • Balakrishnan G; AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India.
  • Nandishaiah R; AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India.
  • Ramachandran V; AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India.
  • Eyermann CJ; AstraZeneca Infection, Innovative Medicines, 35 Gatehouse Drive, Waltham, MA 02451, United States.
  • Reck F; AstraZeneca Infection, Innovative Medicines, 35 Gatehouse Drive, Waltham, MA 02451, United States.
  • Rudrapatna S; AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India.
  • Sambandamurthy VK; AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India.
  • Sharma UK; AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India.
Tuberculosis (Edinb) ; 95(5): 589-98, 2015 Sep.
Article em En | MEDLINE | ID: mdl-26073894
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Bactérias / DNA Topoisomerases Tipo I / Descoberta de Drogas / Inibidores da Topoisomerase I / Mycobacterium tuberculosis / Antituberculosos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Tuberculosis (Edinb) Ano de publicação: 2015 Tipo de documento: Article País de publicação: Reino Unido
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Bactérias / DNA Topoisomerases Tipo I / Descoberta de Drogas / Inibidores da Topoisomerase I / Mycobacterium tuberculosis / Antituberculosos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Tuberculosis (Edinb) Ano de publicação: 2015 Tipo de documento: Article País de publicação: Reino Unido