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HIF-driven SF3B1 induces KHK-C to enforce fructolysis and heart disease.
Mirtschink, Peter; Krishnan, Jaya; Grimm, Fiona; Sarre, Alexandre; Hörl, Manuel; Kayikci, Melis; Fankhauser, Niklaus; Christinat, Yann; Cortijo, Cédric; Feehan, Owen; Vukolic, Ana; Sossalla, Samuel; Stehr, Sebastian N; Ule, Jernej; Zamboni, Nicola; Pedrazzini, Thierry; Krek, Wilhelm.
Afiliação
  • Mirtschink P; Institute of Molecular Health Sciences, ETH Zurich, 8093 Zürich, Switzerland.
  • Krishnan J; Institute of Molecular Health Sciences, ETH Zurich, 8093 Zürich, Switzerland.
  • Grimm F; Institute of Molecular Health Sciences, ETH Zurich, 8093 Zürich, Switzerland.
  • Sarre A; Department of Medicine, University of Lausanne, 1011 Lausanne, Switzerland.
  • Hörl M; Institute of Molecular Systems Biology, ETH Zurich, 8093 Zürich, Switzerland.
  • Kayikci M; MRC-Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK.
  • Fankhauser N; Institute of Molecular Health Sciences, ETH Zurich, 8093 Zürich, Switzerland.
  • Christinat Y; Institute of Molecular Health Sciences, ETH Zurich, 8093 Zürich, Switzerland.
  • Cortijo C; Institute of Molecular Health Sciences, ETH Zurich, 8093 Zürich, Switzerland.
  • Feehan O; Institute of Molecular Health Sciences, ETH Zurich, 8093 Zürich, Switzerland.
  • Vukolic A; Institute of Molecular Health Sciences, ETH Zurich, 8093 Zürich, Switzerland.
  • Sossalla S; Universitätsmedizin Göttingen, Klinik für Kardiologie und Pneumologie, D-37075 Göttingen, and DZHK (German Centre for Cardiovascular Research), Partner Site Göttingen, Germany.
  • Stehr SN; Department of Anesthesiology and Critical Care Medicine, University Hospital Jena, 07747 Jena, Germany.
  • Ule J; MRC-Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK.
  • Zamboni N; Institute of Molecular Systems Biology, ETH Zurich, 8093 Zürich, Switzerland.
  • Pedrazzini T; Department of Medicine, University of Lausanne, 1011 Lausanne, Switzerland.
  • Krek W; Institute of Molecular Health Sciences, ETH Zurich, 8093 Zürich, Switzerland.
Nature ; 522(7557): 444-449, 2015 Jun 25.
Article em En | MEDLINE | ID: mdl-26083752
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfoproteínas / Cardiomiopatia Hipertrófica / Ribonucleoproteína Nuclear Pequena U2 / Subunidade alfa do Fator 1 Induzível por Hipóxia / Frutoquinases / Frutose Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Nature Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Suíça País de publicação: Reino Unido
Texto completo
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PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfoproteínas / Cardiomiopatia Hipertrófica / Ribonucleoproteína Nuclear Pequena U2 / Subunidade alfa do Fator 1 Induzível por Hipóxia / Frutoquinases / Frutose Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Nature Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Suíça País de publicação: Reino Unido