Cinnamomum cassia: an implication of serotonin reuptake inhibition in animal models of depression.
Nat Prod Res
; 30(10): 1212-4, 2016.
Article
em En
| MEDLINE
| ID: mdl-26134381
ABSTRACT
The aim of the study was to explore the traditional use of Cinnamomum cassia against depression. The standardised methanolic extract of the bark of C. cassia was evaluated for antidepressant activity using various behavioural tests, i.e. tail suspension test (TST), forced swim test (FST) and locomotor activity test. The serotonergic and noradrenergic modulation was assessed using 5-hydroxytryptophan (5-HTP)-induced head twitches and yohimbine potentiation tests, respectively. The fluoxetine and phenelzine were used as positive controls in the study. The C. cassia extract significantly decreased the immobility time in TST (maximum effective dose tested was 50 mg/kg) while no effect was observed in FST and locomotor activity test. The extract significantly increased the 5-HTP-induced head twitches while yohimbine-induced lethality remained unaltered. The aforementioned results are similar to that caused by fluoxetine. The standardised methanolic extract of C. cassia demonstrated antidepressant activity that can be attributed to rise in serotonin levels.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Extratos Vegetais
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Inibidores Seletivos de Recaptação de Serotonina
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Cinnamomum aromaticum
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Depressão
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Antidepressivos
Limite:
Animals
Idioma:
En
Revista:
Nat Prod Res
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Paquistão