Your browser doesn't support javascript.
loading
Dual-modality fiber-based OCT-TPL imaging system for simultaneous microstructural and molecular analysis of atherosclerotic plaques.
Wang, Tianyi; McElroy, Austin; Halaney, David; Vela, Deborah; Fung, Edmund; Hossain, Shafat; Phipps, Jennifer; Wang, Bingqing; Yin, Biwei; Feldman, Marc D; Milner, Thomas E.
Afiliação
  • Wang T; Department of Biomedical Engineering, University of Texas at Austin, 1 University Station C0800, Austin, Texas 78712, USA.
  • McElroy A; Department of Biomedical Engineering, University of Texas at Austin, 1 University Station C0800, Austin, Texas 78712, USA.
  • Halaney D; Division of Cardiology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, Texas 78229, USA ; South Texas Veterans Health Care System, San Antonio, Texas 78229, USA.
  • Vela D; Texas Heart Institute, Houston, Texas 77030, USA.
  • Fung E; Department of Biomedical Engineering, University of Texas at Austin, 1 University Station C0800, Austin, Texas 78712, USA.
  • Hossain S; Department of Biomedical Engineering, University of Texas at Austin, 1 University Station C0800, Austin, Texas 78712, USA.
  • Phipps J; Division of Cardiology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, Texas 78229, USA.
  • Wang B; Department of Biomedical Engineering, University of Texas at Austin, 1 University Station C0800, Austin, Texas 78712, USA.
  • Yin B; Department of Biomedical Engineering, University of Texas at Austin, 1 University Station C0800, Austin, Texas 78712, USA.
  • Feldman MD; Division of Cardiology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, Texas 78229, USA ; South Texas Veterans Health Care System, San Antonio, Texas 78229, USA.
  • Milner TE; Department of Biomedical Engineering, University of Texas at Austin, 1 University Station C0800, Austin, Texas 78712, USA.
Biomed Opt Express ; 6(5): 1665-78, 2015 May 01.
Article em En | MEDLINE | ID: mdl-26137371
New optical imaging techniques that provide contrast to study both the anatomy and composition of atherosclerotic plaques can be utilized to better understand the formation, progression and clinical complications of human coronary artery disease. We present a dual-modality fiber-based optical imaging system for simultaneous microstructural and molecular analysis of atherosclerotic plaques that combines optical coherence tomography (OCT) and two-photon luminescence (TPL) imaging. Experimental results from ex vivo human coronary arteries show that OCT and TPL optical contrast in recorded OCT-TPL images is complimentary and in agreement with histological analysis. Molecular composition (e.g., lipid and oxidized-LDL) detected by TPL imaging can be overlaid onto plaque microstructure depicted by OCT, providing new opportunities for atherosclerotic plaque identification and characterization.
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Biomed Opt Express Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Biomed Opt Express Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos