Molecular markers and Schistosoma-associated bladder carcinoma: A systematic review and meta-analysis.
Cancer Epidemiol
; 39(4): 487-96, 2015 Aug.
Article
em En
| MEDLINE
| ID: mdl-26162479
ABSTRACT
BACKGROUND:
Molecular mechanisms and pathogenesis of schistosomal-associated bladder cancer (SABC), one of the most common malignancies in Africa and parts of the Middle East, is still unclear. Identification of host molecular markers involved in schistosomal related bladder carcinogenesis is of value in prediction of high-risk group, early detection and timely intervention.METHODS:
PubMed, Scopus, Google Scholar, Cochrane Library and African Journals Online databases were systematically searched and reviewed. A total of 63 articles reporting 41 host molecular factors were included in the meta-analysis.RESULTS:
Pooled odds ratio demonstrated associations of p53 expression, telomerase activity and sFas with SABC as compared to other schistosomal patients (p53 expression OR=9.46, 95%CI=1.14-78.55, p=0.04; telomerase by TERT OR=37.38, 95%CI=4.17-334.85, p=0.001; telomerase by TRAP OR=10.36, 95%CI=6.08-17.64, p<0.00001; sFas OR=34.37, 95%CI=3.32-355.51, p=0.003). In comparison to bladder cancers of other etiology, positive associations were found between SABC and p15 deletion, p16 deletion, telomerase activity and sFas (p15 deletion OR=4.20, 95%CI=2.58-6.82, p<0.00001; p16 deletion OR=4.93, 95%CI=2.52-9.65, p<0.00001; telomerase by TERT OR=3.01, 95%CI=1.51-5.97, p=0.002; telomerase by TRAP OR=2.66, 95%CI=1.18-6.01, p=0.02; sFas OR=4.50, 95%CI=1.78-11.40, p=0.001). Other identified associations were reported by few numbers of studies to enable reliable interpretation.CONCLUSIONS:
Variations in gene expression or genomic alterations of some molecular markers in SABC as compared to non-SABC or other schistosomal patients were identified. These suggest minute differences in the pathogenesis and physiological profile of SABC, in relation to non-SABC.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Bexiga Urinária
/
Esquistossomose Urinária
/
Biomarcadores Tumorais
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
/
Systematic_reviews
Limite:
Animals
/
Humans
País/Região como assunto:
Africa
/
Asia
Idioma:
En
Revista:
Cancer Epidemiol
Assunto da revista:
EPIDEMIOLOGIA
/
NEOPLASIAS
Ano de publicação:
2015
Tipo de documento:
Article