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Different inhibition of Gßγ-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a Gßγ-dependent regulator of PI3Kγ enzymatic activity.
Shymanets, Aliaksei; Vadas, Oscar; Czupalla, Cornelia; LoPiccolo, Jaclyn; Brenowitz, Michael; Ghigo, Alessandra; Hirsch, Emilio; Krause, Eberhard; Wetzker, Reinhard; Williams, Roger L; Harteneck, Christian; Nürnberg, Bernd.
Afiliação
  • Shymanets A; Department of Pharmacology and Experimental Therapy, Institute of Experimental and Clinical Pharmacology and Toxicology, Eberhard Karls University Hospitals and Clinics, and Interfaculty Centre of Pharmacogenomics and Pharmaceutical Research, University of Tübingen, 72074 Tübingen, Germany.
  • Prajwal; Department of Pharmacology and Experimental Therapy, Institute of Experimental and Clinical Pharmacology and Toxicology, Eberhard Karls University Hospitals and Clinics, and Interfaculty Centre of Pharmacogenomics and Pharmaceutical Research, University of Tübingen, 72074 Tübingen, Germany.
  • Vadas O; Medical Research Council, Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge CB2 0QH, U.K.
  • Czupalla C; Department of Pharmacology and Experimental Therapy, Institute of Experimental and Clinical Pharmacology and Toxicology, Eberhard Karls University Hospitals and Clinics, and Interfaculty Centre of Pharmacogenomics and Pharmaceutical Research, University of Tübingen, 72074 Tübingen, Germany.
  • LoPiccolo J; Department of Molecular Pharmacology, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY 10461, U.S.A.
  • Brenowitz M; Department of Biochemistry, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY 10461, U.S.A.
  • Ghigo A; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Centre, University of Torino, 10126 Turin, Italy.
  • Hirsch E; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Centre, University of Torino, 10126 Turin, Italy.
  • Krause E; Mass Spectrometry Group, Leibniz Institute for Molecular Pharmacology, 13125 Berlin, Germany.
  • Wetzker R; *Department of Molecular Cell Biology, Centre for Molecular Biomedicine, Jena University Hospital, 07745 Jena, Germany.
  • Williams RL; Medical Research Council, Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge CB2 0QH, U.K.
  • Harteneck C; Department of Pharmacology and Experimental Therapy, Institute of Experimental and Clinical Pharmacology and Toxicology, Eberhard Karls University Hospitals and Clinics, and Interfaculty Centre of Pharmacogenomics and Pharmaceutical Research, University of Tübingen, 72074 Tübingen, Germany.
  • Nürnberg B; Department of Pharmacology and Experimental Therapy, Institute of Experimental and Clinical Pharmacology and Toxicology, Eberhard Karls University Hospitals and Clinics, and Interfaculty Centre of Pharmacogenomics and Pharmaceutical Research, University of Tübingen, 72074 Tübingen, Germany bernd.nue
Biochem J ; 469(1): 59-69, 2015 Jul 01.
Article em En | MEDLINE | ID: mdl-26173259
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Subunidades beta da Proteína de Ligação ao GTP / Subunidades gama da Proteína de Ligação ao GTP / Classe Ib de Fosfatidilinositol 3-Quinase / Anticorpos Monoclonais Murinos Limite: Animals / Humans Idioma: En Revista: Biochem J Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Alemanha País de publicação: Reino Unido
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Subunidades beta da Proteína de Ligação ao GTP / Subunidades gama da Proteína de Ligação ao GTP / Classe Ib de Fosfatidilinositol 3-Quinase / Anticorpos Monoclonais Murinos Limite: Animals / Humans Idioma: En Revista: Biochem J Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Alemanha País de publicação: Reino Unido