RNA binding proteins as regulators of immune cell biology.
Clin Exp Immunol
; 183(1): 37-49, 2016 Jan.
Article
em En
| MEDLINE
| ID: mdl-26201441
ABSTRACT
Sequence-specific RNA binding proteins (RBP) are important regulators of the immune response. RBP modulate gene expression by regulating splicing, polyadenylation, localization, translation and decay of target mRNAs. Increasing evidence suggests that RBP play critical roles in the development, activation and function of lymphocyte populations in the immune system. This review will discuss the post-transcriptional regulation of gene expression by RBP during lymphocyte development, with particular focus on the Tristetraprolin family of RBP.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
RNA Mensageiro
/
Linfócitos
/
Processamento Pós-Transcricional do RNA
/
Proteínas de Ligação a RNA
/
Tristetraprolina
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Clin Exp Immunol
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Reino Unido