Synthesis, antiviral activity and structure-activity relationship of 1-(1-aryl-4,5-dihydro-1H-imidazoline)-3-chlorosulfonylureas and products of their cyclization.

Rzadkowska, Marzena; Szacon, Elzbieta; Kaczor, Agnieszka A; Rajtar, Barbara; Swiatek, Lukasz; Polz-Dacewicz, Malgorzata; Matosiuk, Dariusz

Rzadkowska, Marzena; Szacon, Elzbieta; Kaczor, Agnieszka A; Rajtar, Barbara; Swiatek, Lukasz; Polz-Dacewicz, Malgorzata; Matosiuk, Dariusz.

Afiliação

Rzadkowska M; a Department of Synthesis and Chemical Technology of Pharmaceutical Substances with Computer Modeling Lab, Faculty of Pharmacy with Division of Medical Analytics , Medical University of Lublin , Lublin , Poland .
Szacon E; a Department of Synthesis and Chemical Technology of Pharmaceutical Substances with Computer Modeling Lab, Faculty of Pharmacy with Division of Medical Analytics , Medical University of Lublin , Lublin , Poland .
Kaczor AA; a Department of Synthesis and Chemical Technology of Pharmaceutical Substances with Computer Modeling Lab, Faculty of Pharmacy with Division of Medical Analytics , Medical University of Lublin , Lublin , Poland .
Rajtar B; b School of Pharmacy, University of Eastern Finland , Kuopio , Finland , and.
Swiatek L; c Department of Virology , Medical University of Lublin, I Faculty of Medicine with Dentistry Division , Lublin , Poland.
Polz-Dacewicz M; c Department of Virology , Medical University of Lublin, I Faculty of Medicine with Dentistry Division , Lublin , Poland.
Matosiuk D; c Department of Virology , Medical University of Lublin, I Faculty of Medicine with Dentistry Division , Lublin , Poland.

J Enzyme Inhib Med Chem ; 31(5): 787-95, 2016 Oct.

Article em En | MEDLINE | ID: mdl-26212601

Assuntos

Antivirais/química; Antivirais/farmacologia; Enterovirus Humano B/efeitos dos fármacos; Simplexvirus/efeitos dos fármacos; Ureia/química; Ureia/farmacologia; Animais; Antivirais/síntese química; Chlorocebus aethiops; Infecções por Coxsackievirus/tratamento farmacológico; Ciclização; Herpes Simples/tratamento farmacológico; Imidazolinas/síntese química; Imidazolinas/química; Imidazolinas/farmacologia; Modelos Moleculares; Estrutura Molecular; Relação Estrutura-Atividade; Ácidos Sulfônicos/síntese química; Ácidos Sulfônicos/química; Ácidos Sulfônicos/farmacologia; Ureia/síntese química; Células Vero

Palavras-chave

1-(1-Aryl-4,5dihydro-1H-imidazoline)-3-chlorosulfonylourea derivatives; Antiviral activity; Coxsackievirus B3,; Herpes simplex; structureactivity relationship

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Ureia / Simplexvirus / Enterovirus Humano B Limite: Animals Idioma: En Revista: J Enzyme Inhib Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Polônia País de publicação: Reino Unido

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