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Disease-associated mutation in SRSF2 misregulates splicing by altering RNA-binding affinities.
Zhang, Jian; Lieu, Yen K; Ali, Abdullah M; Penson, Alex; Reggio, Kathryn S; Rabadan, Raul; Raza, Azra; Mukherjee, Siddhartha; Manley, James L.
Afiliação
  • Zhang J; Department of Biological Sciences, Columbia University, New York, NY 10027;
  • Lieu YK; Irving Cancer Research Center, Columbia University, New York, NY 10032;
  • Ali AM; Irving Cancer Research Center, Columbia University, New York, NY 10032;
  • Penson A; Department of Systems Biology, Columbia University, New York, NY 10032;
  • Reggio KS; Department of Biological Sciences, Columbia University, New York, NY 10027;
  • Rabadan R; Department of Systems Biology, Columbia University, New York, NY 10032; Department of Biomedical Informatics, Columbia University, New York, NY 10032;
  • Raza A; Irving Cancer Research Center, Columbia University, New York, NY 10032; Division of Hematology and Oncology, Department of Medicine, Columbia University, New York, NY 10032.
  • Mukherjee S; Irving Cancer Research Center, Columbia University, New York, NY 10032; Division of Hematology and Oncology, Department of Medicine, Columbia University, New York, NY 10032 sm3252@cumc.columbia.edu jlm2@columbia.edu.
  • Manley JL; Department of Biological Sciences, Columbia University, New York, NY 10027; sm3252@cumc.columbia.edu jlm2@columbia.edu.
Proc Natl Acad Sci U S A ; 112(34): E4726-34, 2015 Aug 25.
Article em En | MEDLINE | ID: mdl-26261309
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ribonucleoproteínas / RNA / Proteínas Nucleares / Splicing de RNA / Mutação Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2015 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ribonucleoproteínas / RNA / Proteínas Nucleares / Splicing de RNA / Mutação Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2015 Tipo de documento: Article País de publicação: Estados Unidos