A novel stereo bioactive metabolite isolated from an endophytic fungus induces caspase dependent apoptosis and STAT-3 inhibition in human leukemia cells.

Pathania, Anup Singh; Guru, Santosh Kumar; Ul Ashraf, Nissar; Riyaz-Ul-Hassan, Syed; Ali, Asif; Abdullah Tasduq, Sheikh; Malik, Fayaz; Bhushan, Shashi

Pathania, Anup Singh; Guru, Santosh Kumar; Ul Ashraf, Nissar; Riyaz-Ul-Hassan, Syed; Ali, Asif; Abdullah Tasduq, Sheikh; Malik, Fayaz; Bhushan, Shashi.

Afiliação

Pathania AS; Division of Cancer Pharmacology, CSIR-Indian Institute of Integrative Medicine, Jammu 180001, India; Academy of Scientific and Innovative Research (AcSIR), Anusandhan Bhawan, New Delhi, India.
Guru SK; Division of Cancer Pharmacology, CSIR-Indian Institute of Integrative Medicine, Jammu 180001, India.
Ul Ashraf N; PK-PD-Toxicology Division, CSIR-Indian Institute of Integrative Medicine, Jammu 180001, India; Academy of Scientific and Innovative Research (AcSIR), Anusandhan Bhawan, New Delhi, India.
Riyaz-Ul-Hassan S; Microbial Biotechnology Division, CSIR-Indian Institute of Integrative Medicine, Jammu 180001, India; Academy of Scientific and Innovative Research (AcSIR), Anusandhan Bhawan, New Delhi, India.
Ali A; Natural Product Division, CSIR-Indian Institute of Integrative Medicine, Jammu 180001, India; Academy of Scientific and Innovative Research (AcSIR), Anusandhan Bhawan, New Delhi, India.
Abdullah Tasduq S; PK-PD-Toxicology Division, CSIR-Indian Institute of Integrative Medicine, Jammu 180001, India; Academy of Scientific and Innovative Research (AcSIR), Anusandhan Bhawan, New Delhi, India.
Malik F; Division of Cancer Pharmacology, CSIR-Indian Institute of Integrative Medicine, Jammu 180001, India; Academy of Scientific and Innovative Research (AcSIR), Anusandhan Bhawan, New Delhi, India.
Bhushan S; Division of Cancer Pharmacology, CSIR-Indian Institute of Integrative Medicine, Jammu 180001, India; Academy of Scientific and Innovative Research (AcSIR), Anusandhan Bhawan, New Delhi, India. Electronic address: sbhushan@iiim.ac.in.

Eur J Pharmacol ; 765: 75-85, 2015 Oct 15.

Article em En | MEDLINE | ID: mdl-26291658

Assuntos

Apoptose/fisiologia; Caspases/biossíntese; Cryptosporidium/metabolismo; Endófitos/metabolismo; Leucemia/metabolismo; Fator de Transcrição STAT3/antagonistas & inibidores; Antineoplásicos/química; Antineoplásicos/metabolismo; Antineoplásicos/farmacologia; Apoptose/efeitos dos fármacos; Criptosporidiose; Cryptosporidium/química; Cryptosporidium/isolamento & purificação; Endófitos/química; Endófitos/isolamento & purificação; Indução Enzimática/efeitos dos fármacos; Indução Enzimática/fisiologia; Células HL-60; Humanos; Células K562; Fator de Transcrição STAT3/metabolismo; Estereoisomerismo

Palavras-chave

(R)-5-hydroxy-2-methylchroman-4-one (HMC); Apoptosis; Endophyte; Proteosome inhibitor; STAT-3

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia / Apoptose / Caspases / Cryptosporidium / Fator de Transcrição STAT3 / Endófitos Limite: Humans Idioma: En Revista: Eur J Pharmacol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Índia País de publicação: Holanda

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