Conservative or radical surgery for pediatric papillary thyroid carcinoma: A systematic review of the literature.
Int J Pediatr Otorhinolaryngol
; 79(10): 1620-4, 2015 Oct.
Article
em En
| MEDLINE
| ID: mdl-26300408
ABSTRACT
BACKGROUND:
Pediatric papillary thyroid carcinoma (PTC) is characterized by an aggressive clinical course. Early diagnosis is a challenge and treatment consists principally of partial or total thyroidectomy±neck dissection and radioactive iodine therapy. Due to the rarity of PTC in children, there is no consensus on optimal surgical treatment. METHODS ANDRESULTS:
A literature search was carried out using PubMed, Embase, Medline, Cochrane and Web of Science. Seven studies (489 patients) investigating the outcome of surgically managed pediatric PTC were identified. No clear advantage in survival or recurrence rate was found for total thyroidectomy compared to other surgical approaches.CONCLUSION:
Despite the aggressive behavior of PTC, prognosis is good, with low mortality. After removal of disease and prevention of recurrence, reduction of iatrogenic complications are a priority in this age group. Due to the paucity of available evidence, this review cannot recommend conservative or radical surgery for pediatric papillary thyroid carcinoma. To answer this question, we recommend the establishment of a randomized controlled trial with adequately matched baseline variables.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esvaziamento Cervical
/
Tireoidectomia
/
Neoplasias da Glândula Tireoide
/
Carcinoma
Tipo de estudo:
Clinical_trials
/
Prognostic_studies
/
Screening_studies
/
Systematic_reviews
Limite:
Adolescent
/
Child
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Child, preschool
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Int J Pediatr Otorhinolaryngol
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Reino Unido