Overexpression and gene amplification of both ERBB2 and EGFR in an esophageal squamous cell carcinoma revealed by fluorescence in situ hybridization, multiplex ligation-dependent probe amplification and immunohistochemistry.

Oyama, Takeru; Okamoto, Koichi; Nakamura, Ritsuko; Tajiri, Ryosuke; Ikeda, Hiroko; Ninomiya, Itasu; Ooi, Akishi

Oyama, Takeru; Okamoto, Koichi; Nakamura, Ritsuko; Tajiri, Ryosuke; Ikeda, Hiroko; Ninomiya, Itasu; Ooi, Akishi.

Afiliação

Oyama T; Department of Molecular and Cellular Pathology, Graduate School of Medical Science, Kanazawa University, Ishikawa, Japan.
Okamoto K; Department of Gastroenterologic Surgery, Graduate School of Medical Science, Kanazawa University, Ishikawa, Japan.
Nakamura R; Department of Molecular and Cellular Pathology, Graduate School of Medical Science, Kanazawa University, Ishikawa, Japan.
Tajiri R; Department of Molecular and Cellular Pathology, Graduate School of Medical Science, Kanazawa University, Ishikawa, Japan.
Ikeda H; Pathology Section, University Hospital, Kanazawa University, Ishikawa, Japan.
Ninomiya I; Department of Gastroenterologic Surgery, Graduate School of Medical Science, Kanazawa University, Ishikawa, Japan.
Ooi A; Department of Molecular and Cellular Pathology, Graduate School of Medical Science, Kanazawa University, Ishikawa, Japan.

Pathol Int ; 65(11): 608-13, 2015 Nov.

Article em En | MEDLINE | ID: mdl-26314265

Assuntos

Carcinoma de Células Escamosas/metabolismo; Receptores ErbB/genética; Neoplasias Esofágicas/metabolismo; Amplificação de Genes/genética; Receptor ErbB-2/genética; Idoso; Carcinoma de Células Escamosas do Esôfago; Amplificação de Genes/fisiologia; Humanos; Imuno-Histoquímica/métodos; Hibridização in Situ Fluorescente/métodos; Masculino; Receptor ErbB-2/metabolismo

Palavras-chave

CCND1; EGFR; ERBB2; FISH; MLPA; esophageal cancer; gene amplification

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Esofágicas / Carcinoma de Células Escamosas / Amplificação de Genes / Receptor ErbB-2 / Receptores ErbB Limite: Aged / Humans / Male Idioma: En Revista: Pathol Int Assunto da revista: PATOLOGIA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Japão País de publicação: Austrália

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