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Diagnostic performances of [18F]fluorocholine positron emission tomography in brain tumors.
Sollini, Martina; Sghedoni, Roberto; Erba, Paola A; Cavuto, Silvio; Froio, Armando; De Berti, Gianni; Pisanello, Anna; Fraternali, Alessandro; Iori, Michele; Iaccarino, Corrado; Iori, Mauro; Asti, Mattia; Filice, Angelina; Versari, Annibale.
Afiliação
  • Sollini M; Unit of Nuclear Medicine, Santa Maria Nuova Hospital, Institute for Research and Care of Reggio Emilia, Reggio Emilia, Italy - martinasollini@msn.com.
  • Sghedoni R; Unit of Medical Physics, Santa Maria Nuova Hospital, Institute for Research and Care of Reggio Emilia, Reggio Emilia, Italy.
  • Erba PA; Regional Center of Nuclear Medicine, University of Pisa, Pisa, Italy.
  • Cavuto S; Unit of Infrastructure Research and Statistics, Santa Maria Nuova Hospital, Institute for Research and Care of Reggio Emilia, Reggio Emilia, Italy.
  • Froio A; Unit of Nuclear Medicine, Santa Maria Nuova Hospital, Institute for Research and Care of Reggio Emilia, Reggio Emilia, Italy.
  • De Berti G; Neuroradiology Section, Villa Verde Clinic, Reggio Emilia, Italy.
  • Pisanello A; Unit of Neurology, Santa Maria Nuova Hospital, Institute for Research and Care of Reggio Emilia, Reggio Emilia, Italy.
  • Fraternali A; Unit of Nuclear Medicine, Santa Maria Nuova Hospital, Institute for Research and Care of Reggio Emilia, Reggio Emilia, Italy.
  • Iori M; Unit of Nuclear Medicine, Santa Maria Nuova Hospital, Institute for Research and Care of Reggio Emilia, Reggio Emilia, Italy.
  • Iaccarino C; Unit of Neurosurgery and Neurotraumatology, Parma University Hospital, Parma, Italy.
  • Iori M; Unit of Emergency Neurosurgery, Santa Maria Nuova Hospital, Institute for Research and Care of Reggio Emilia, Reggio Emilia, Italy.
  • Asti M; Unit of Medical Physics, Santa Maria Nuova Hospital, Institute for Research and Care of Reggio Emilia, Reggio Emilia, Italy.
  • Filice A; Unit of Nuclear Medicine, Santa Maria Nuova Hospital, Institute for Research and Care of Reggio Emilia, Reggio Emilia, Italy.
  • Versari A; Unit of Nuclear Medicine, Santa Maria Nuova Hospital, Institute for Research and Care of Reggio Emilia, Reggio Emilia, Italy.
Q J Nucl Med Mol Imaging ; 62(2): 209-219, 2018 Jun.
Article em En | MEDLINE | ID: mdl-26329494
BACKGROUND: Brain tumors characterization by molecular imaging that allows the depiction of brain lesions metabolic pattern is crucial. Our study aimed to: 1) to evaluate the diagnostic performances of [18F]fluoroethylcholine positron emission tomography/computed tomography ([18F]FECH PET/CT), and 2) correlate PET imaging derived parameters of [18F]FECH to survival in brain tumors. METHODS: From 2009 to 2012, we enrolled 30 patients who underwent [18F]FECH PET/CT. Final diagnosis was established by clinical and radiological follow-up. RESULTS: Final diagnosis was consistent with tumor disease in 27/30 cases. In 3/30 cases tumor disease was ruled out. [18F]FECH PET/CT resulted true positive and negative in 21/30 and 9/30 patients, respectively. Sensitivity, specificity, positive predictive value, negative predictive value and accuracy of [18F]FECH PET/CT were 78%, 100%, 100%, 33%, and 80%, respectively. Mean and maximum standardized uptake value (SUVmean and SUVmax) resulted statistically correlated to histology (P=0.0255 and P=0.0222, respectively). Using a SUVmax cut-off of 2.0 or 3.2, we distinguished between low- and high-grade gliomas with a good specificity (70% and 80%, respectively). SUVmax and histology resulted correlated to overall survival and disease related survival at multivariate analysis. CONCLUSIONS: Our results, worthy of further investigations, show high diagnostic performances of [18F]FECH PET/CT, and a correlation between PET imaging derived parameters and survival.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Colina / Compostos Radiofarmacêuticos / Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada Tipo de estudo: Diagnostic_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Q J Nucl Med Mol Imaging Assunto da revista: MEDICINA NUCLEAR Ano de publicação: 2018 Tipo de documento: Article País de publicação: Itália

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Colina / Compostos Radiofarmacêuticos / Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada Tipo de estudo: Diagnostic_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Q J Nucl Med Mol Imaging Assunto da revista: MEDICINA NUCLEAR Ano de publicação: 2018 Tipo de documento: Article País de publicação: Itália