Electron Transfer Pathways in Cholesterol Synthesis.
Lipids
; 50(10): 927-36, 2015 Oct.
Article
em En
| MEDLINE
| ID: mdl-26344922
ABSTRACT
Cholesterol synthesis in the endoplasmic reticulum requires electron input at multiple steps and utilizes both NADH and NADPH as the electron source. Four enzymes catalyzing five steps in the pathway require electron input squalene monooxygenase, lanosterol demethylase, sterol 4α-methyl oxidase, and sterol C5-desaturase. The electron-donor proteins for these enzymes include cytochrome P450 reductase and the cytochrome b5 pathway. Here I review the evidence for electron donor protein requirements with these enzymes, the evidence for additional electron donor pathways, and the effect of deletion of these redox enzymes on cholesterol and lipid metabolism.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Citocromos b5
/
Colesterol
/
NAD
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Lipids
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Estados Unidos