Regulated expression of virulence gene mviN provides protective immunity and colonization control of Salmonella in poultry.
Vaccine
; 33(41): 5365-5370, 2015 Oct 05.
Article
em En
| MEDLINE
| ID: mdl-26354731
ABSTRACT
Current live attenuated vaccines for control of Salmonella in poultry persist in the ceca and may persist in the environment. In this paper we report the construction and characterization of the vaccine efficacy of a Salmonella mutant strain with inducible mviN expression and rapid clearance from the host. The mutant was effective in oral immunization of the broiler chicken host against a virulent Salmonella oral challenge strain, having a mean 7×10(6)CFU/g in the ceca of unvaccinated controls compared to a mean 2×10(3)CFU/g in the ceca of vaccinated chickens at 4 weeks post-challenge (6 weeks of age). The mutant strain also demonstrated immunogenicity, reduced organ colonization, and rapid clearance in broiler chickens within 3 weeks of inoculation.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Salmonella
/
Salmonelose Animal
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Proteínas de Bactérias
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Regulação Bacteriana da Expressão Gênica
Limite:
Animals
Idioma:
En
Revista:
Vaccine
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Estados Unidos