Defective production of interleukin-1 and tumour necrosis factor-alpha by stimulated monocytes from patients with systemic lupus erythematosus.
Acta Med Hung
; 46(4): 245-52, 1989.
Article
em En
| MEDLINE
| ID: mdl-2636360
ABSTRACT
Interleukin-1 and tumour necrosis factor-alpha activity by E. coli lipopolysaccharide-triggered monocytes was studied in patients with systemic lupus erythematosus in various stages of activity. Monocytes from both groups of SLE patients produced significantly less tumour necrosis factor-alpha activity than those of age and sex matched healthy controls. However, interleukin-1 activity was only significantly reduced in patients with active stage of the disease. These findings indicate further immunoregulatory disturbances in monocyte function concerning SLE.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Monócitos
/
Interleucina-1
/
Fator de Necrose Tumoral alfa
/
Lúpus Eritematoso Sistêmico
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Acta Med Hung
Ano de publicação:
1989
Tipo de documento:
Article
País de afiliação:
Hungria