Overexpression of PI3K-p110α in the progression of uterine cervical neoplasia and its correlation with pAkt and DJ-1.
Eur J Gynaecol Oncol
; 36(4): 389-93, 2015.
Article
em En
| MEDLINE
| ID: mdl-26390688
ABSTRACT
OBJECTIVE:
To investigate the expression of PI3K-p110α, pAkt, PTEN, the signaling molecules from PI3K/Akt signaling pathway, DJ-1, an oncoprotein and HSP90a, a molecular chaperone, and their correlation in uterine cervical neoplasia, in order to elucidate their role in cervical carcinogenesis. MATERIALS ANDMETHODS:
Using immunohistochemistry, the authors analyzed the expression of PI3K-p110α, pAkt, PTEN, DJ-1 and HSP90α, and their correlation in ten normal tissues, cervical intraepithelial neoplasia (CIN) including 30 CIN1 and 31 CIN3, and 33 cases of invasive squamous cell carcinoma (SCC).RESULTS:
The expression of all proteins significantly increased in CIN3 compared to CIN1, and only the expression of PI3K-p110α significantly increased in invasive SCC compared to CIN3. There was a significant positive correlation between the expression of PI3K-p110α and DJ-1, as well as PI3K-p110α and pAkt in CIN3 and invasive SCC.CONCLUSION:
Overexpression of PI3K-p110α is associated with progression of uterine cervical neoplasia, and the expression of pAkt and DJ-1 is positively correlated with PI3K-p110α expression in this process.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias do Colo do Útero
/
Proteínas Oncogênicas
/
Peptídeos e Proteínas de Sinalização Intracelular
/
Proteínas Proto-Oncogênicas c-akt
/
Classe Ia de Fosfatidilinositol 3-Quinase
Limite:
Female
/
Humans
Idioma:
En
Revista:
Eur J Gynaecol Oncol
Ano de publicação:
2015
Tipo de documento:
Article