Bisacremines E-G, Three Polycyclic Dimeric Acremines Produced by Acremonium persicinum SC0105.
Org Lett
; 17(19): 4922-5, 2015 Oct 02.
Article
em En
| MEDLINE
| ID: mdl-26399982
ABSTRACT
Three dimeric acremines, bisacremines E-G (1-3), with an unusual carbon skeleton were isolated from cultures of the soil-derived fungus Acremonium persicinum SC0105. Their structures were elucidated by spectroscopic analysis, X-ray diffraction, and ECD/TDDFT computations. Compound 3 exhibited inhibitory effects on the production of TNF-α, IL-6, and NO in LPS-stimulated macrophages. A biogenetic pathway with a [4 + 2] cycloaddition as the key reaction is proposed for 1-3.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Terpenos
/
Acremonium
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Org Lett
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2015
Tipo de documento:
Article