Refractory chronic cough due to gastroesophageal reflux: Definition, mechanism and management.
World J Methodol
; 5(3): 149-56, 2015 Sep 26.
Article
em En
| MEDLINE
| ID: mdl-26413488
ABSTRACT
Refractory chronic cough due to gastroesophageal reflux is a troublesome condition unresponsive to the standard medical anti-reflux therapy. Its underlying mechanisms may include incomplete acid suppression, non-acid reflux, transient lower esophageal sphincter relaxations and esophageal hypersensitivity. The diagnosis of this disorder depends on both the findings of multi-channel intraluminal impedance-pH monitoring and the subsequent intensified anti-reflux therapy. The strategies of pharmacological treatment for refractory chronic cough due to reflux include the optimization of proton pump inhibitors and add-on therapies with histamine H2 receptor antagonists, baclofen and gabapentin. However, the further study is needed to satisfy its management.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
World J Methodol
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
China