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Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair.
Day, Felix R; Ruth, Katherine S; Thompson, Deborah J; Lunetta, Kathryn L; Pervjakova, Natalia; Chasman, Daniel I; Stolk, Lisette; Finucane, Hilary K; Sulem, Patrick; Bulik-Sullivan, Brendan; Esko, Tõnu; Johnson, Andrew D; Elks, Cathy E; Franceschini, Nora; He, Chunyan; Altmaier, Elisabeth; Brody, Jennifer A; Franke, Lude L; Huffman, Jennifer E; Keller, Margaux F; McArdle, Patrick F; Nutile, Teresa; Porcu, Eleonora; Robino, Antonietta; Rose, Lynda M; Schick, Ursula M; Smith, Jennifer A; Teumer, Alexander; Traglia, Michela; Vuckovic, Dragana; Yao, Jie; Zhao, Wei; Albrecht, Eva; Amin, Najaf; Corre, Tanguy; Hottenga, Jouke-Jan; Mangino, Massimo; Smith, Albert V; Tanaka, Toshiko; Abecasis, Goncalo; Andrulis, Irene L; Anton-Culver, Hoda; Antoniou, Antonis C; Arndt, Volker; Arnold, Alice M; Barbieri, Caterina; Beckmann, Matthias W; Beeghly-Fadiel, Alicia; Benitez, Javier; Bernstein, Leslie.
Afiliação
  • Day FR; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
  • Ruth KS; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK.
  • Thompson DJ; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, CB1 8RN, UK.
  • Lunetta KL; Boston University School of Public Health, Department of Biostatistics. Boston, Massachusetts 02118, USA.
  • Pervjakova N; NHLBI's and Boston University's Framingham Heart Study, Framingham, Massachusetts 01702-5827, USA.
  • Chasman DI; Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia.
  • Stolk L; Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia.
  • Finucane HK; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215.
  • Sulem P; Harvard Medical School, Boston, MA 02115, USA.
  • Bulik-Sullivan B; Department of Internal Medicine, Erasmus MC, 3015GE Rotterdam, the Netherlands.
  • Esko T; Netherlands Consortium on Health Aging and National Genomics Initiative, 2300 RC Leiden, the Netherlands.
  • Johnson AD; Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.
  • Elks CE; Department of Mathematics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139-4307, USA.
  • Franceschini N; deCODE genetics/Amgen, Inc., IS-101 Reykjavik, Iceland.
  • He C; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
  • Altmaier E; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Brody JA; Medical and Population Genetics, Broad Institute, Cambridge, MA 02142, US.
  • Franke LL; Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia.
  • Huffman JE; Division of Endocrinology, Boston Children's Hospital, Boston, MA 02115, USA.
  • Keller MF; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
  • McArdle PF; Broad Institute of the Massachusetts Institute of Technology and Harvard University, 140 Cambridge 02142, MA, USA.
  • Nutile T; NHLBI's and Boston University's Framingham Heart Study, Framingham, Massachusetts 01702-5827, USA.
  • Porcu E; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
  • Robino A; Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA.
  • Rose LM; Department of Epidemiology, Indiana University Richard M. Fairbanks School of Public Health, Indianapolis, IN 46202, USA.
  • Schick UM; Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN 46202, USA.
  • Smith JA; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany.
  • Teumer A; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany.
  • Traglia M; Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany.
  • Vuckovic D; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle Washington 98101 USA.
  • Yao J; Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
  • Zhao W; NHLBI's and Boston University's Framingham Heart Study, Framingham, Massachusetts 01702-5827, USA.
  • Albrecht E; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
  • Amin N; Merck Pharmaceuticals, 33 Avenue Louis Pasteur, Boston, MA 02115, United States.
  • Corre T; Program in Personalized Medicine, Division of Endocrinology, Diabetes and Nutrition - University of Maryland School of Medicine, USA. Baltimore, MD 21201.
  • Hottenga JJ; Institute of Genetics and Biophysics - CNR, via Pietro Castellino 111, 80131, Naples, Italy.
  • Mangino M; Institute of Genetics and Biomedical Research, National Research Council, Cagliari, 09042 Sardinia, Italy.
  • Smith AV; University of Sassari, Department of Biomedical Sciences, Sassari, 07100 Sassari, Italy.
  • Tanaka T; Center for Statistical Genetics, Ann Arbor, University of Michigan, Michigan 48109-2029, USA.
  • Abecasis G; Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", 34137 Trieste, Italy.
  • Andrulis IL; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215.
  • Anton-Culver H; Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Seattle, WA 98109-1024, USA.
  • Antoniou AC; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
  • Arndt V; Institute for Community Medicine, University Medicine Greifswald, 17475 Greifswald, Germany.
  • Arnold AM; Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milano, Italy.
  • Barbieri C; Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", 34137 Trieste, Italy.
  • Beckmann MW; Department of Clinical Medical Sciences, Surgical and Health, University of Trieste, 34149 Trieste, Italy.
  • Beeghly-Fadiel A; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, California, USA.
  • Benitez J; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
  • Bernstein L; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Nat Genet ; 47(11): 1294-1303, 2015 Nov.
Article em En | MEDLINE | ID: mdl-26414677
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Transdução de Sinais / Proteína BRCA1 / Predisposição Genética para Doença / Reparo do DNA / Hipotálamo Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Adult / Female / Humans / Middle aged Idioma: En Revista: Nat Genet Assunto da revista: GENETICA MEDICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Reino Unido País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Transdução de Sinais / Proteína BRCA1 / Predisposição Genética para Doença / Reparo do DNA / Hipotálamo Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Adult / Female / Humans / Middle aged Idioma: En Revista: Nat Genet Assunto da revista: GENETICA MEDICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Reino Unido País de publicação: Estados Unidos