Microfluidics-based single-step preparation of injection-ready polymeric nanosystems for medical imaging and drug delivery.
Nanoscale
; 7(40): 16983-93, 2015 Oct 28.
Article
em En
| MEDLINE
| ID: mdl-26415866
ABSTRACT
Translation of therapeutic polymeric nanosystems to patients and industry requires simplified, reproducible and scalable methods for assembly and loading. A single-step in-line process based on nanocoprecipitation of oxazoline-siloxane block copolymers in flow-focusing poly(dimethylsiloxane) microfluidics was designed to manufacture injection-ready nanosystems. Nanosystem characteristics could be controlled by copolymer concentration, block length and chemistry, microchannel geometry, flow rate, aqueous/organic flow rate ratio and payload concentration. The well-tolerated nanosystems exhibited differential cell binding and payload delivery and could confer sensitivity to photodynamic therapy to HeLa cancer cells. Such injection-ready nanosystems carrying drugs, diagnostic or functional materials may facilitate translation to clinical application.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fotoquimioterapia
/
Diagnóstico por Imagem
/
Portadores de Fármacos
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Técnicas Analíticas Microfluídicas
/
Nanopartículas
/
Neoplasias
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
En
Revista:
Nanoscale
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
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