PTPRD gene associated with blood pressure response to atenolol and resistant hypertension.
J Hypertens
; 33(11): 2278-85, 2015 Nov.
Article
em En
| MEDLINE
| ID: mdl-26425837
ABSTRACT
OBJECTIVE:
The aim of this study is to identify single-nucleotide polymorphisms (SNPs) influencing blood pressure (BP) response to the ß-blocker atenolol.METHODS:
Genome-wide association analysis of BP response to atenolol monotherapy was performed in 233 white participants with uncomplicated hypertension in the pharmacogenomic evaluation of antihypertensive responses study. Forty-two polymorphisms with P less than 10 for association with either diastolic or systolic response to atenolol monotherapy were validated in four independent groups of hypertensive individuals (total nâ=â2114).RESULTS:
In whites, two polymorphisms near the gene PTPRD (rs12346562 and rs1104514) were associated with DBP response to atenolol (Pâ=â3.2â×â10 and Pâ=â5.9â×â10, respectively) with directionally opposite association for response to hydrochlorothiazide in another group of 228 whites (Pâ=â0.0018 and Pâ=â0.00012). A different polymorphism (rs10739150) near PTPRD was associated with response to atenolol in 150 black hypertensive individuals (Pâ=â8.25â×â10). rs12346562 had a similar trend in association with response to bisoprolol (a different ß-blocker) in 207 Finnish men in the genetics of drug responsiveness in essential hypertension study. In addition, an intronic single-nucleotide polymorphism (rs4742610) in the PTPRD gene was associated with resistant hypertension in whites and Hispanics in the international verapamil SR trandolapril study (meta-analysis Pâ=â3.2â×â10).CONCLUSION:
PTPRD was identified as a novel locus potentially associated with BP response to atenolol and resistant hypertension in multiple ethnic groups.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Atenolol
/
Pressão Sanguínea
/
Proteínas Tirosina Fosfatases Classe 2 Semelhantes a Receptores
/
Hipertensão
/
Anti-Hipertensivos
Tipo de estudo:
Risk_factors_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Hypertens
Ano de publicação:
2015
Tipo de documento:
Article