[Reverse genetics systems for orbiviruses reveal the essential mechanisms in their replication].

ABSTRACT

The members of Orbivirus genus within the family Reoviridae cause severe arthropod-born diseases mainly in ruminants and equids. In addition, the orbiviruses, which can infect humans, have been reported. In the last decade, the molecular and structural studies for orbiviruses, including Bluetongue virus (BTV), has made a great progress. Especially, a reverse genetics system (RG) for BTV, developed soon after Orhoreovirus and Rotavirus, is a major breakthrough. Here, I introduced the recent findings in orbivirus replication, especially the function of an enzymatic protein, VP6.