Cardiac allograft survival in mice treated with IL-2-PE40.
Proc Natl Acad Sci U S A
; 86(3): 1008-12, 1989 Feb.
Article
em En
| MEDLINE
| ID: mdl-2644640
ABSTRACT
IL-2-PE40 is a chimeric protein composed of human interleukin 2 (IL-2) genetically fused to the amino terminus of a modified form of Pseudomonas exotoxin lacking its cell recognition domain. IL-2-PE40, which is extremely cytotoxic to IL-2 receptor-positive cells, was examined for its ability to prevent graft rejection in mice in which activation of T cells is prominent. We demonstrate that intraperitoneally administered IL-2-PE40 specifically and significantly prolongs the survival of vascularized heart allografts in mice. The chimeric toxin, IL-2-PE40, offers an alternative approach to the treatment of autoimmune diseases and transplant rejection in humans.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Toxinas Bacterianas
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Proteínas Recombinantes
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Imunotoxinas
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Transplante de Coração
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Interleucina-2
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ADP Ribose Transferases
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Fatores de Virulência
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Exotoxinas
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Sobrevivência de Enxerto
Limite:
Animals
Idioma:
En
Revista:
Proc Natl Acad Sci U S A
Ano de publicação:
1989
Tipo de documento:
Article