Poly(ADP-ribosyl)ation as a new posttranslational modification of YB-1.
Biochimie
; 119: 36-44, 2015 Dec.
Article
em En
| MEDLINE
| ID: mdl-26453809
ABSTRACT
Multifunctional Y-box binding protein 1 (YB-1) is actively studied as one of the components of cellular response to genotoxic stress. However, the precise role of YB-1 in the process of DNA repair is still obscure. In the present work we report for the first time new posttranslational modification of YB-1 - poly(ADP-ribosyl)ation, catalyzed by one of the main regulatory enzymes of DNA repair - poly(ADP-ribose)polymerase 1 (PARP1) in the presence of model DNA substrate carrying multiple DNA lesions. Therefore, poly(ADP-ribosyl)ation of YB-1 catalyzed with PARP1, can be stimulated by damaged DNA. The observed property of YB-1 underlines its ability to participate in the DNA repair by its involvement in the regulatory cascades of DNA repair.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dano ao DNA
/
Regulação para Cima
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Processamento de Proteína Pós-Traducional
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Reparo do DNA
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Proteína 1 de Ligação a Y-Box
/
Poli(ADP-Ribose) Polimerase-1
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Modelos Biológicos
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Biochimie
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Federação Russa