Cembranoids from the Gum Resin of Boswellia carterii as Potential Antiulcerative Colitis Agents.
J Nat Prod
; 78(10): 2322-31, 2015 Oct 23.
Article
em En
| MEDLINE
| ID: mdl-26457560
ABSTRACT
Eight new cembranoids, boscartins A-H (1, 2, and 4-9), and the known incensole oxide were isolated from the gum resin of Boswellia carterii. The absolute configurations of 1, 2, 4, and incensole oxide were unequivocally resolved using single-crystal X-ray diffraction analysis with Cu Kα radiation, and the absolute configuration of 5 was resolved via electronic circular dichroism data. The antiulcerative colitis activities of the compounds were evaluated in an in vitro x-box-binding protein 1 (XBP 1) transcriptional activity assay using dual luciferase reporter detection. At 10 µM, compounds 1, 5, 6, and 7 significantly activated XBP 1 transcription with EC50 values of 0.34, 1.14, 0.88, and 0.42 µM, respectively, compared with the pGL3-basic vector control.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Resinas Vegetais
/
Colite
/
Boswellia
/
Diterpenos
/
Antiulcerosos
Idioma:
En
Revista:
J Nat Prod
Ano de publicação:
2015
Tipo de documento:
Article