alpha-IFN treatment does not induce Ki-ras expression in hairy-cell leukemia patients.
Blut
; 58(2): 83-4, 1989 Feb.
Article
em En
| MEDLINE
| ID: mdl-2645955
ABSTRACT
alpha-Interferon (IFN) is effective in the treatment of hairy-cell leukemia (HCL), but the treatment is sometimes over a long period. Biological changes such as the increase of tumorigenicity can occur rapidly in vivo as a result of beginning this treatment; an increase in c-Ki-ras oncogene expression has also been observed. In order to determine whether the findings observed in vitro would be duplicated in an in vivo system, we decided to analyze the Ki-ras RNA and protein levels in the lymphocytes of three HCL patients, compared with these levels in seven normal donors and one non-treated HCL patients. Ki-ras was not activated by IFN, at least not in lymphocytes. Therefore, the data suggest that the drug could be used for long-term therapy with relatively low risk to the patients.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Leucemia de Células Pilosas
/
Interferon Tipo I
/
Regulação da Expressão Gênica
/
Genes ras
Limite:
Humans
Idioma:
En
Revista:
Blut
Ano de publicação:
1989
Tipo de documento:
Article
País de afiliação:
França