Cocaine inhibits store-operated Ca2+ entry in brain microvascular endothelial cells: critical role for sigma-1 receptors.

Brailoiu, G Cristina; Deliu, Elena; Console-Bram, Linda M; Soboloff, Jonathan; Abood, Mary E; Unterwald, Ellen M; Brailoiu, Eugen

Brailoiu, G Cristina; Deliu, Elena; Console-Bram, Linda M; Soboloff, Jonathan; Abood, Mary E; Unterwald, Ellen M; Brailoiu, Eugen.

Afiliação

Brailoiu GC; Department of Pharmaceutical Sciences, Jefferson College of Pharmacy, Thomas Jefferson University, Philadelphia, PA 19107, U.S.A.
Deliu E; Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA 19140, U.S.A.
Console-Bram LM; Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA 19140, U.S.A.
Soboloff J; Fels Institute for Cancer Research and Molecular Biology and Department of Medical Genetics & Molecular Biochemistry, Temple University School of Medicine, Philadelphia, PA 19140, U.S.A.
Abood ME; Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA 19140, U.S.A. Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, PA 19140, U.S.A.
Unterwald EM; Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA 19140, U.S.A. Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, U.S.A.
Brailoiu E; Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA 19140, U.S.A. ebrailou@temple.edu.

Biochem J ; 473(1): 1-5, 2016 Jan 01.

Article em En | MEDLINE | ID: mdl-26467159

Assuntos

Cálcio/metabolismo; Cocaína/farmacologia; Células Endoteliais/metabolismo; Microvasos/metabolismo; Receptores sigma/fisiologia; Animais; Canais de Cálcio/metabolismo; Sinalização do Cálcio/efeitos dos fármacos; Sinalização do Cálcio/fisiologia; Células Cultivadas; Células Endoteliais/efeitos dos fármacos; Microvasos/efeitos dos fármacos; Ratos; Receptores sigma/agonistas; Receptor Sigma-1

Palavras-chave

calcium; calcium imaging; endoplasmic reticulum; endothelial cell; sigma-1 receptor; store-operated calcium entry

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cálcio / Receptores sigma / Cocaína / Células Endoteliais / Microvasos Limite: Animals Idioma: En Revista: Biochem J Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Reino Unido

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