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Unstable coronary plaque characteristics are associated with high-sensitivity cardiac troponin T and N-terminal Pro-Brain Natriuretic Peptide.
Altintas, Sibel; Cardinaels, Eline P M; Versteylen, Mathijs O; Joosen, Ivo A; Seifert, Milan; Wildberger, Joachim E; Crijns, Harry J; Nelemans, Patricia J; Van Dieijen-Visser, Marja P; Mingels, Alma M A; Das, Marco; Kietselaer, Bas L.
Afiliação
  • Altintas S; Department of Cardiology, Maastricht University Medical Center (MUMC+), P. Debyelaan 25, PO Box 5800, 6202 AZ, Maastricht, The Netherlands; Cardiovascular Research Institute, School for Cardiovascular Diseases, P. Debyelaan 25, PO Box 5800, 6202 AZ, Maastricht, The Netherlands.
  • Cardinaels EP; Central Diagnostic Laboratory, Department of Clinical Chemistry, MUMC+, P. Debyelaan 25, PO Box 5800, 6202 AZ, Maastricht, The Netherlands.
  • Versteylen MO; Department of Cardiology, Maastricht University Medical Center (MUMC+), P. Debyelaan 25, PO Box 5800, 6202 AZ, Maastricht, The Netherlands.
  • Joosen IA; Department of Cardiology, Maastricht University Medical Center (MUMC+), P. Debyelaan 25, PO Box 5800, 6202 AZ, Maastricht, The Netherlands.
  • Seifert M; Department of Cardiology, Maastricht University Medical Center (MUMC+), P. Debyelaan 25, PO Box 5800, 6202 AZ, Maastricht, The Netherlands.
  • Wildberger JE; Cardiovascular Research Institute, School for Cardiovascular Diseases, P. Debyelaan 25, PO Box 5800, 6202 AZ, Maastricht, The Netherlands; Department of Radiology, MUMC+, P. Debyelaan 25, PO Box 5800, 6202 AZ, Maastricht, The Netherlands.
  • Crijns HJ; Department of Cardiology, Maastricht University Medical Center (MUMC+), P. Debyelaan 25, PO Box 5800, 6202 AZ, Maastricht, The Netherlands; Cardiovascular Research Institute, School for Cardiovascular Diseases, P. Debyelaan 25, PO Box 5800, 6202 AZ, Maastricht, The Netherlands.
  • Nelemans PJ; Department of Epidemiology, CAPHRI School for Public Health and Primary Care, Maastricht University Faculty of Health, Medicine and Life Sciences, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.
  • Van Dieijen-Visser MP; Central Diagnostic Laboratory, Department of Clinical Chemistry, MUMC+, P. Debyelaan 25, PO Box 5800, 6202 AZ, Maastricht, The Netherlands.
  • Mingels AM; Cardiovascular Research Institute, School for Cardiovascular Diseases, P. Debyelaan 25, PO Box 5800, 6202 AZ, Maastricht, The Netherlands; Central Diagnostic Laboratory, Department of Clinical Chemistry, MUMC+, P. Debyelaan 25, PO Box 5800, 6202 AZ, Maastricht, The Netherlands.
  • Das M; Cardiovascular Research Institute, School for Cardiovascular Diseases, P. Debyelaan 25, PO Box 5800, 6202 AZ, Maastricht, The Netherlands; Department of Radiology, MUMC+, P. Debyelaan 25, PO Box 5800, 6202 AZ, Maastricht, The Netherlands.
  • Kietselaer BL; Department of Cardiology, Maastricht University Medical Center (MUMC+), P. Debyelaan 25, PO Box 5800, 6202 AZ, Maastricht, The Netherlands; Cardiovascular Research Institute, School for Cardiovascular Diseases, P. Debyelaan 25, PO Box 5800, 6202 AZ, Maastricht, The Netherlands; Department of Radiolo
J Cardiovasc Comput Tomogr ; 10(1): 82-8, 2016.
Article em En | MEDLINE | ID: mdl-26481512
ABSTRACT

BACKGROUND:

Unstable plaque characteristics on coronary CT angiography (CTA), serum high-sensitivity cardiac troponin T (hs-cTnT) and N-terminal Pro-Brain Natriuretic Peptide (NT-proBNP) concentrations are associated with cardiovascular events.

OBJECTIVE:

To investigate the association between coronary CTA defined quantifiable plaque characteristics, hs-cTnT and NT-proBNP.

METHODS:

81 consecutive stable chest pain patients with an intermediate-to-high risk were analyzed. Coronary CTA was performed using a 64-slice multidetector-row CT-scanner. Total coronary plaque volume, calcified volume, non-calcified volume, plaque burden, remodeling index (RI) and number of plaques were measured using dedicated software. A total plaque score ("Sum plaque score") incorporating total plaque volume, RI, plaque burden and number of plaques was defined. Hs-cTnT and NT-proBNP concentrations were measured in serum samples before coronary CTA.

RESULTS:

Univariate regression analysis demonstrated significant associations of hs-cTnT and NT-proBNP with total plaque volume (r hs-cTnT = .256; r NT-proBNP = .270), calcified volume (r hs-cTnT = .344; r NT-proBNP = .344), RI (r hs-cTnT = .335; r NT-proBNP = .342) and number of plaques (r hs-cTnT = .355; r NT-proBNP = .301) (all P values ≤ .021). Non-calcified plaque volume showed no association with hs-cTnT and NT-proBNP (r hs-cTnT = .050; r NT-proBNP = .087; P value = .660 and P value = .442). The "Sum plaque score" showed the highest correlation compared to other plaque parameters (r hs-cTnT = .362; r NT-proBNP = .409; P value = .001 and P value ≤ .001).

CONCLUSION:

Our data suggest that coronary plaque morphology parameters, derived by dedicated software, are associated with serum hs-cTnT and NT-proBNP concentrations.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença da Artéria Coronariana / Tomografia Computadorizada por Raios X / Troponina T / Peptídeo Natriurético Encefálico Tipo de estudo: Diagnostic_studies / Etiology_studies / Prevalence_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: En Revista: J Cardiovasc Comput Tomogr Assunto da revista: ANGIOLOGIA / CARDIOLOGIA / RADIOLOGIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença da Artéria Coronariana / Tomografia Computadorizada por Raios X / Troponina T / Peptídeo Natriurético Encefálico Tipo de estudo: Diagnostic_studies / Etiology_studies / Prevalence_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: En Revista: J Cardiovasc Comput Tomogr Assunto da revista: ANGIOLOGIA / CARDIOLOGIA / RADIOLOGIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Holanda