Oxidation resistance 1 (OXR1) participates in silkworm defense against bacterial infection through the JNK pathway.
Insect Sci
; 24(1): 17-26, 2017 Feb.
Article
em En
| MEDLINE
| ID: mdl-26507465
Bacterial infection causes enhanced reactive oxygen species (ROS) levels in insects. Oxidation resistance 1 (OXR1) plays an antioxidant role in eukaryotic organisms, including insects. In this report, we demonstrated that Pseudomonas aeruginosa and Staphylococcus aureus infection and hydrogen peroxide (H2 O2 ) injection induced the expression of specific transcriptional isoforms of OXR1 in larval silkworms. We further showed that a Jun kinase (JNK) pathway inhibitor, SP600125, down-regulated expression of OXR1 during infection, leading to elevated H2 O2 levels in the hemolymph, resulting in lower viability of the injected bacteria inside the silkworm larvae. Our study suggests that OXR1 participates in protecting larval silkworms from oxidative stress and bacterial infection through the JNK pathway.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bombyx
/
Proteínas Quinases JNK Ativadas por Mitógeno
Limite:
Animals
Idioma:
En
Revista:
Insect Sci
Ano de publicação:
2017
Tipo de documento:
Article
País de publicação:
Austrália