Structure-activity relationship of indoloquinoline analogs anti-MRSA.

Zhao, Min; Kamada, Tomonori; Takeuchi, Aya; Nishioka, Hiromi; Kuroda, Teruo; Takeuchi, Yasuo

Zhao, Min; Kamada, Tomonori; Takeuchi, Aya; Nishioka, Hiromi; Kuroda, Teruo; Takeuchi, Yasuo.

Afiliação

Zhao M; Faculty of Pharmaceutical Sciences, Okayama University, Kitaku-Tsushima-naka 1-1-1, Okayama 700-8530, Japan.
Kamada T; Faculty of Pharmaceutical Sciences, Okayama University, Kitaku-Tsushima-naka 1-1-1, Okayama 700-8530, Japan.
Takeuchi A; Faculty of Pharmaceutical Sciences, Okayama University, Kitaku-Tsushima-naka 1-1-1, Okayama 700-8530, Japan.
Nishioka H; Faculty of Pharmaceutical Sciences, Okayama University, Kitaku-Tsushima-naka 1-1-1, Okayama 700-8530, Japan.
Kuroda T; Faculty of Pharmaceutical Sciences, Okayama University, Kitaku-Tsushima-naka 1-1-1, Okayama 700-8530, Japan.
Takeuchi Y; Faculty of Pharmaceutical Sciences, Okayama University, Kitaku-Tsushima-naka 1-1-1, Okayama 700-8530, Japan. Electronic address: take@pharm.okayama-u.ac.jp.

Bioorg Med Chem Lett ; 25(23): 5551-4, 2015 Dec 01.

Article em En | MEDLINE | ID: mdl-26522949

ABSTRACT

ABSTRACT

Indolo[3,2-b]quinoline analogs (3a-3s), 4-(acridin-9-ylamino) phenol hydrochloride (4), benzofuro[3,2-b]quinoline (3t), indeno[1,2-b]quinolines (3u and 3v) have been synthesized. Those compounds were found to exhibit anti-bacterial activity towards Methicillin-resistant Staphylococcus aureus (anti-MRSA activity). Structure-activity relationship studies were conducted that indoloquinoline ring, benzofuroquinoline ring and 4-aminophenol group are essential structure for anti-MRSA activity.

Assuntos

Indóis/química; Staphylococcus aureus Resistente à Meticilina/efeitos dos fármacos; Quinolinas/química; Quinolinas/farmacologia; Antibacterianos/síntese química; Antibacterianos/química; Antibacterianos/farmacologia; Farmacorresistência Bacteriana/efeitos dos fármacos; Testes de Sensibilidade Microbiana; Quinolinas/síntese química; Relação Estrutura-Atividade

Palavras-chave

Anti-MRSA; Benzofuroquinoline; Indenoquinoline; Indoloquinoline; Structureactivity

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinolinas / Staphylococcus aureus Resistente à Meticilina / Indóis Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Japão

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