N-Methyl, N-propynyl-2-phenylethylamine (MPPE), a Selegiline Analog, Attenuates MPTP-induced Dopaminergic Toxicity with Guaranteed Behavioral Safety: Involvement of Inhibitions of Mitochondrial Oxidative Burdens and p53 Gene-elicited Pro-apoptotic Change.

Shin, Eun-Joo; Nam, Yunsung; Lee, Ji Won; Nguyen, Phuong-Khue Thi; Yoo, Ji Eun; Tran, The-Vinh; Jeong, Ji Hoon; Jang, Choon-Gon; Oh, Young J; Youdim, Moussa B H; Lee, Phil Ho; Nabeshima, Toshitaka; Kim, Hyoung-Chun

Shin, Eun-Joo; Nam, Yunsung; Lee, Ji Won; Nguyen, Phuong-Khue Thi; Yoo, Ji Eun; Tran, The-Vinh; Jeong, Ji Hoon; Jang, Choon-Gon; Oh, Young J; Youdim, Moussa B H; Lee, Phil Ho; Nabeshima, Toshitaka; Kim, Hyoung-Chun.

Afiliação

Shin EJ; Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon, 200-701, Republic of Korea.
Nam Y; Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon, 200-701, Republic of Korea.
Lee JW; Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon, 200-701, Republic of Korea.
Nguyen PT; Hutecs Korea Pharm Co., Ltd., Osan, 18111, Republic of Korea.
Yoo JE; Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon, 200-701, Republic of Korea.
Tran TV; Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon, 200-701, Republic of Korea.
Jeong JH; Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon, 200-701, Republic of Korea.
Jang CG; Department of Pharmacology, College of Medicine, Chung-Ang University, Seoul, 156-756, Republic of Korea.
Oh YJ; Department of Pharmacology, School of Pharmacy, Sungkyunkwan University, Suwon, 440-746, Republic of Korea.
Youdim MBH; Department of Systems Biology, Yonsei University College of Life Science and Biotechnology, Seoul, 120-749, Republic of Korea.
Lee PH; Eve Topf Centers of Excellence for Neurodegenerative Diseases Research, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, 31096, Israel.
Nabeshima T; National Creative Research Initiative Center for Catalytic Organic Reactions, Department of Chemistry, Kangwon National University, Chunchon, 200-701, Republic of Korea.
Kim HC; Department of Regional Pharmaceutical Care and Sciences, Graduate School of Pharmaceutical Sciences, Meijo University, Nagoya, 468-8503, Japan.

Mol Neurobiol ; 53(9): 6251-6269, 2016 11.

Article em En | MEDLINE | ID: mdl-26563498

Assuntos

Apoptose/efeitos dos fármacos; Comportamento Animal; Neurônios Dopaminérgicos/patologia; Mitocôndrias/metabolismo; Fenetilaminas/farmacologia; Selegilina/análogos & derivados; Proteína Supressora de Tumor p53/genética; 1-Metil-4-Fenil-1,2,3,6-Tetra-Hidropiridina; Animais; Caspase 3/metabolismo; Condicionamento Psicológico; Citocromos c/metabolismo; Citosol/metabolismo; Neurônios Dopaminérgicos/efeitos dos fármacos; Neurônios Dopaminérgicos/metabolismo; Complexo I de Transporte de Elétrons; Locomoção/efeitos dos fármacos; Potencial da Membrana Mitocondrial/efeitos dos fármacos; Camundongos Endogâmicos C57BL; Mitocôndrias/efeitos dos fármacos; Monoaminoxidase/metabolismo; Neostriado/efeitos dos fármacos; Neostriado/metabolismo; Oxirredução; Estresse Oxidativo/efeitos dos fármacos; Fenetilaminas/química; Ligação Proteica/efeitos dos fármacos; Selegilina/química; Selegilina/farmacologia; Sulfonamidas/farmacologia; Superóxido Dismutase/metabolismo; Proteína Supressora de Tumor p53/metabolismo; Proteína Desacopladora 2/metabolismo; Proteína bcl-X/metabolismo

Palavras-chave

Behavioral safety; Mitochondria; N-Methyl, N-propynyl-2-phenylethylamine; Oxidative stress; Parkinson's disease; Pro-apoptosis; Selegiline; p53 gene knockout mice

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenetilaminas / Comportamento Animal / Selegilina / Proteína Supressora de Tumor p53 / Apoptose / Neurônios Dopaminérgicos / Mitocôndrias Limite: Animals Idioma: En Revista: Mol Neurobiol Assunto da revista: BIOLOGIA MOLECULAR / NEUROLOGIA Ano de publicação: 2016 Tipo de documento: Article País de publicação: Estados Unidos

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