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The hematopoietic tumor suppressor interferon regulatory factor 8 (IRF8) is upregulated by the antimetabolite cytarabine in leukemic cells involving the zinc finger protein ZNF224, acting as a cofactor of the Wilms' tumor gene 1 (WT1) protein.
Montano, Giorgia; Ullmark, Tove; Jernmark-Nilsson, Helena; Sodaro, Gaetano; Drott, Kristina; Costanzo, Paola; Vidovic, Karina; Gullberg, Urban.
Afiliação
  • Montano G; Department of Hematology and Transfusion Medicine, Medical Faculty, University of Lund, Lund, Sweden. Electronic address: giorgia.montano@med.lu.se.
  • Ullmark T; Department of Hematology and Transfusion Medicine, Medical Faculty, University of Lund, Lund, Sweden. Electronic address: tove.ullmark@med.lu.se.
  • Jernmark-Nilsson H; Department of Hematology and Transfusion Medicine, Medical Faculty, University of Lund, Lund, Sweden. Electronic address: helena.jernmark_nilsson@med.lu.se.
  • Sodaro G; Department of Molecular Medicine, and Medical Biotechnology, University of Naples Federico II, Naples, Italy. Electronic address: sodaro@unina.it.
  • Drott K; Department of Hematology and Transfusion Medicine, Medical Faculty, University of Lund, Lund, Sweden. Electronic address: kristina.drott@med.lu.se.
  • Costanzo P; Department of Molecular Medicine, and Medical Biotechnology, University of Naples Federico II, Naples, Italy. Electronic address: paola.costanzo@unina.it.
  • Vidovic K; Department of Hematology and Transfusion Medicine, Medical Faculty, University of Lund, Lund, Sweden. Electronic address: karina.vidovic@med.lu.se.
  • Gullberg U; Department of Hematology and Transfusion Medicine, Medical Faculty, University of Lund, Lund, Sweden. Electronic address: urban.gullberg@med.lu.se.
Leuk Res ; 40: 60-7, 2016 Jan.
Article em En | MEDLINE | ID: mdl-26563595
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia / Regulação para Cima / Dedos de Zinco / Citarabina / Proteínas WT1 / Fatores Reguladores de Interferon / Antimetabólitos Antineoplásicos Limite: Humans Idioma: En Revista: Leuk Res Ano de publicação: 2016 Tipo de documento: Article País de publicação: Reino Unido
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia / Regulação para Cima / Dedos de Zinco / Citarabina / Proteínas WT1 / Fatores Reguladores de Interferon / Antimetabólitos Antineoplásicos Limite: Humans Idioma: En Revista: Leuk Res Ano de publicação: 2016 Tipo de documento: Article País de publicação: Reino Unido