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Synthesis of apoptotic chalcone analogues in HepG2 human hepatocellular carcinoma cells.
Park, Cheon-Soo; Ahn, Yongchel; Lee, Dahae; Moon, Sung Won; Kim, Ki Hyun; Yamabe, Noriko; Hwang, Gwi Seo; Jang, Hyuk Jai; Lee, Heesu; Kang, Ki Sung; Lee, Jae Wook.
Afiliação
  • Park CS; Department of Surgery, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung 210-711, Republic of Korea.
  • Ahn Y; Department of Hematology and Oncology, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung 210-711, Republic of Korea.
  • Lee D; College of Korean Medicine, Gachon University, Seongnam 461-701, Republic of Korea.
  • Moon SW; Department of Chemistry, Gangneung Wonju National University, Gangneung 210-340, Republic of Korea; Natural Product Research Center, Korea Institute of Science and Technology, Gangneung 210-340, Republic of Korea.
  • Kim KH; Natural Product Research Laboratory, School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Republic of Korea.
  • Yamabe N; College of Korean Medicine, Gachon University, Seongnam 461-701, Republic of Korea.
  • Hwang GS; College of Korean Medicine, Gachon University, Seongnam 461-701, Republic of Korea.
  • Jang HJ; Department of Surgery, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung 210-711, Republic of Korea.
  • Lee H; Department of Oral Anatomy, College of Dentistry, Gangneung Wonju National University, 201-340, Republic of Korea.
  • Kang KS; College of Korean Medicine, Gachon University, Seongnam 461-701, Republic of Korea. Electronic address: kkang@gachon.ac.kr.
  • Lee JW; Natural Product Research Center, Korea Institute of Science and Technology, Gangneung 210-340, Republic of Korea; Department of Biological Chemistry, University of Science and Technology (UST), Daejeon 305-333, Republic of Korea. Electronic address: jwlee5@kist.re.kr.
Bioorg Med Chem Lett ; 25(24): 5705-7, 2015 Dec 15.
Article em En | MEDLINE | ID: mdl-26564263
ABSTRACT
Eight chalcone analogues were prepared and evaluated for their cytotoxic effects in human hepatoma HepG2 cells. Compound 5 had a potent cytotoxic effect. The percentage of apoptotic cells was significantly higher in compound 5-treated cells than in control cells. Exposure to compound 5 for 24h induced cleavage of caspase-8 and -3, and poly (ADP-ribose) polymerase (PARP). Our findings suggest that compound 5 is the active chalcone analogue that contributes to cell death in HepG2 cells via the extrinsic apoptotic pathway.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Chalcona / Antineoplásicos Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Chalcona / Antineoplásicos Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2015 Tipo de documento: Article