CYP2C19 and CES1 polymorphisms and efficacy of clopidogrel and aspirin dual antiplatelet therapy in patients with symptomatic intracranial atherosclerotic disease.

Hoh, Brian L; Gong, Yan; McDonough, Caitrin W; Waters, Michael F; Royster, Adrienne J; Sheehan, Tiffany O; Burkley, Ben; Langaee, Taimour Y; Mocco, J; Zuckerman, Scott L; Mummareddy, Nishit; Stephens, Marcus L; Ingram, Christie; Shaffer, Christian M; Denny, Joshua C; Brilliant, Murray H; Kitchner, Terrie E; Linneman, James G; Roden, Dan M; Johnson, Julie A

CYP2C19 and CES1 polymorphisms and efficacy of clopidogrel and aspirin dual antiplatelet therapy in patients with symptomatic intracranial atherosclerotic disease.

Hoh, Brian L; Gong, Yan; McDonough, Caitrin W; Waters, Michael F; Royster, Adrienne J; Sheehan, Tiffany O; Burkley, Ben; Langaee, Taimour Y; Mocco, J; Zuckerman, Scott L; Mummareddy, Nishit; Stephens, Marcus L; Ingram, Christie; Shaffer, Christian M; Denny, Joshua C; Brilliant, Murray H; Kitchner, Terrie E; Linneman, James G; Roden, Dan M; Johnson, Julie A.

Afiliação

Hoh BL; Departments of 1 Neurosurgery and.
Gong Y; Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, College of Pharmacy, University of Florida, Gainesville, Florida; and
McDonough CW; Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, College of Pharmacy, University of Florida, Gainesville, Florida; and
Waters MF; Neurology, and.
Royster AJ; Departments of 1 Neurosurgery and.
Sheehan TO; Neurology, and.
Burkley B; Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, College of Pharmacy, University of Florida, Gainesville, Florida; and
Langaee TY; Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, College of Pharmacy, University of Florida, Gainesville, Florida; and
Mocco J; Departments of 4 Neurosurgery.
Zuckerman SL; Departments of 4 Neurosurgery.
Mummareddy N; Departments of 4 Neurosurgery.
Stephens ML; Departments of 4 Neurosurgery.
Ingram C; Medicine, and.
Shaffer CM; Medicine, and.
Denny JC; Medicine, and.
Brilliant MH; Center for Human Genetics Research and.
Kitchner TE; Center for Human Genetics Research and.
Linneman JG; Biomedical Informatics Research Center, Marshfield Clinic Research Foundation, Marshfield, Wisconsin.
Roden DM; Medicine, and.
Johnson JA; Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee, and.

J Neurosurg ; 124(6): 1746-51, 2016 Jun.

Article em En | MEDLINE | ID: mdl-26587656

Assuntos

Aspirina/uso terapêutico; Hidrolases de Éster Carboxílico/genética; Citocromo P-450 CYP2C19/genética; Arteriosclerose Intracraniana/tratamento farmacológico; Inibidores da Agregação Plaquetária/uso terapêutico; Ticlopidina/análogos & derivados; Idoso; Clopidogrel; Feminino; Frequência do Gene; Técnicas de Genotipagem; Heterozigoto; Humanos; Arteriosclerose Intracraniana/epidemiologia; Arteriosclerose Intracraniana/genética; Ataque Isquêmico Transitório/tratamento farmacológico; Ataque Isquêmico Transitório/epidemiologia; Ataque Isquêmico Transitório/genética; Estimativa de Kaplan-Meier; Masculino; Infarto do Miocárdio/tratamento farmacológico; Infarto do Miocárdio/epidemiologia; Infarto do Miocárdio/genética; Polimorfismo de Nucleotídeo Único; Estudos Prospectivos; Acidente Vascular Cerebral/tratamento farmacológico; Acidente Vascular Cerebral/epidemiologia; Acidente Vascular Cerebral/genética; Ticlopidina/uso terapêutico

Palavras-chave

CES1 = carboxylesterase 1; CYP = cytochrome P450; ICAD = intracranial atherosclerotic disease; LOF = loss of function; MI = myocardial infarction; PTAS = percutaneous transluminal angioplasty and stenting; SAMMPRIS = Stenting and Aggressive Medical Management for Preventing Recurrent stroke in Intracranial Stenosis; SNP = single-nucleotide polymorphism; TIA = transient ischemic attack; WASID = Warfarin-Aspirin Symptomatic Intracranial Disease; antiplatelet; intracranial atherosclerotic disease; intracranial stenosis; pharmacogenomics; stroke; transient ischemic attack; vascular disorders

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ticlopidina / Inibidores da Agregação Plaquetária / Hidrolases de Éster Carboxílico / Arteriosclerose Intracraniana / Aspirina / Citocromo P-450 CYP2C19 Tipo de estudo: Clinical_trials / Diagnostic_studies / Observational_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male Idioma: En Revista: J Neurosurg Ano de publicação: 2016 Tipo de documento: Article País de publicação: Estados Unidos

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