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Extensively drug-resistant tuberculosis in a young child after travel to India.
Salazar-Austin, Nicole; Ordonez, Alvaro A; Hsu, Alice Jenh; Benson, Jane E; Mahesh, Mahadevappa; Menachery, Elizabeth; Razeq, Jafar H; Salfinger, Max; Starke, Jeffrey R; Milstone, Aaron M; Parrish, Nicole; Nuermberger, Eric L; Jain, Sanjay K.
Afiliação
  • Salazar-Austin N; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Ordonez AA; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore
  • Hsu AJ; Department of Pharmacy, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Benson JE; Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Mahesh M; Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Menachery E; Howard County Health Department, Columbia, MD, USA.
  • Razeq JH; Maryland Department of Health and Mental Hygiene, Laboratories Administration, Baltimore, MD, USA.
  • Salfinger M; National Jewish Health Mycobacteriology Laboratory, Denver, CO, USA.
  • Starke JR; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
  • Milstone AM; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Hospital Epidemiology and Infection Control, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Parrish N; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Nuermberger EL; Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Jain SK; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore
Lancet Infect Dis ; 15(12): 1485-91, 2015 Dec.
Article em En | MEDLINE | ID: mdl-26607130
ABSTRACT
Extensively drug-resistant (XDR) tuberculosis is becoming increasingly prevalent worldwide, but little is known about XDR tuberculosis in young children. In this Grand Round we describe a 2-year-old child from the USA who developed pneumonia after a 3 month visit to India. Symptoms resolved with empirical first-line tuberculosis treatment; however, a XDR strain of Mycobacterium tuberculosis grew in culture. In the absence of clinical or microbiological markers, low-radiation exposure pulmonary CT imaging was used to monitor treatment response, and guide an individualised drug regimen. Management was complicated by delays in diagnosis, uncertainties about drug selection, and a scarcity of child-friendly formulations. Treatment has been successful so far, and the child is in remission. This report of XDR tuberculosis in a young child in the USA highlights the risks of acquiring drug-resistant tuberculosis overseas, and the unique challenges in management of tuberculosis in this susceptible population.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose Pulmonar / Pneumonia Bacteriana / Tuberculose Extensivamente Resistente a Medicamentos Tipo de estudo: Diagnostic_studies Limite: Child, preschool / Female / Humans País/Região como assunto: America do norte / Asia Idioma: En Revista: Lancet Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose Pulmonar / Pneumonia Bacteriana / Tuberculose Extensivamente Resistente a Medicamentos Tipo de estudo: Diagnostic_studies Limite: Child, preschool / Female / Humans País/Região como assunto: America do norte / Asia Idioma: En Revista: Lancet Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos