Identification of a New Ribonucleoside Inhibitor of Ebola Virus Replication.
Viruses
; 7(12): 6233-40, 2015 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-26633464
ABSTRACT
The current outbreak of Ebola virus (EBOV) in West Africa has claimed the lives of more than 15,000 people and highlights an urgent need for therapeutics capable of preventing virus replication. In this study we screened known nucleoside analogues for their ability to interfere with EBOV replication. Among them, the cytidine analogue ß-d-N4-hydroxycytidine (NHC) demonstrated potent inhibitory activities against EBOV replication and spread at non-cytotoxic concentrations. Thus, NHC constitutes an interesting candidate for the development of a suitable drug treatment against EBOV.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Replicação Viral
/
Citidina
/
Ebolavirus
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
En
Revista:
Viruses
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
França